Protein detail
KLC1
Kinesin light chain 1 (KLC 1)
Protein symbol KLC1 | UniProt ID | EVMP score 0.60 |
Frequency 18 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Kinesin light chain 1 (KLC 1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
hKLC1BhKLC1GhKLC1JhKLC1NhKLC1PhKLC1RhKLC1SKLCKNS2KNS2A
Gene Description
Kinesin light chain 1
Chromosome
14
Position
103561896-103714249
Frequency
18
EVMP Score
0.60
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-6811434 copi dependent golgi to er retrograde traffic
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-983231 factors involved in megakaryocyte development and platelet production
- R-hsa-8856688 golgi to er retrograde transport
- R-hsa-109582 hemostasis
- R-hsa-6811442 intra golgi and retrograde golgi to er traffic
- R-hsa-983189 kinesins
- R-hsa-199991 membrane trafficking
- R-hsa-2132295 mhc class ii antigen presentation
- R-hsa-5625970 rho gtpases activate ktn1
- R-hsa-195258 rho gtpase effectors
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KLC1 | PRKAB1 | Q9Y478 | S | 521 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:20074060 |
| KLC1 | PRKAB1 | Q9Y478 | S | 524 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:20074060 |
| KLC1 | PRKAA2 | P54646 | S | 521 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:20074060 |
| KLC1 | PRKAA2 | P54646 | S | 524 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:20074060 |
| KLC1 | MAPK3 | P27361 | S | 460 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:21385839ProtMapper:21385839 |
| KLC1 | MAPK1 | P28482 | S | 460 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:21385839ProtMapper:21385839 |
| KLC1 | PRKAA1 | Q13131 | S | 521 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK03 | P27361 | KLC1 | Q07866 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:21385839ProtMapper:21385839 |
| KLC1 | Q07866 | TOR1A | O14656 | Yes | Yes | No | SIGNOR | SIGNOR:14970196 |
| MK01 | P28482 | KLC1 | Q07866 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:21385839ProtMapper:21385839 |
| AAPK1 | Q13131 | KLC1 | Q07866 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20074060 |
Protein Complex Composition
13 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KIF5BKLC1LARP1UBCYWHABYWHAEYWHAGYWHAHYWHAQYWHAZ | P0CG48P27348P31946P33176P61981P62258P63104Q04917Q07866Q6PKG0 | 1:1:1:1:1:1:1:1:1:1 | CompleatCFinder | Compleat:HC9806 | ||
| KLC1 | Q07866 | 2 | PDB | PDB:7ai4PDB:7aie | ||
| KLC1SYNE4 | Q07866Q8N205 | 0:0 | hu.MAP2 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
573
Mass
65,310
Sequence
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
Alternative Products
Event=Alternative splicing; Named isoforms=10; Comment=Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms.; Name=A; IsoId=Q07866-1; Sequence=Displayed; Name=C; Synonyms=KLC1C, R, KLC1R; IsoId=Q07866-2; Sequence=VSP_008018; Name=G; Synonyms=KLC1G; IsoId=Q07866-3; Sequence=VSP_008017; Name=J; Synonyms=KLC1J; IsoId=Q07866-4; Sequence=VSP_008019, VSP_008020; Name=K; Synonyms=KLC1K; IsoId=Q07866-5; Sequence=VSP_008019; Name=N; Synonyms=KLC1N; IsoId=Q07866-6; Sequence=VSP_008017, VSP_008019, VSP_008020; Name=P; Synonyms=KLC1P; IsoId=Q07866-7; Sequence=VSP_008021; Name=S; Synonyms=KLC1S, Q, KLC1Q; IsoId=Q07866-8; Sequence=VSP_008017, VSP_008018; Name=I; IsoId=Q07866-9; Sequence=VSP_023323; Name=D; Synonyms=KLC1D; IsoId=Q07866-10; Sequence=VSP_046424
Alternative Sequence
542..573; VSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR -> MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH (in isoform P); 542..550; Missing (in isoform G, isoform N and isoform S); 550; G -> GDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGMKRASSLNVLNVGGKAAEDRFQ (in isoform I); 551..573; GVSGRASFCGKRQQQQWPGRRHR -> MRKMKLGLVN (in isoform C and isoform S); 551..573; GVSGRASFCGKRQQQQWPGRRHR -> DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLFVENDSSSSGLEDATAN (in isoform D); 551; G -> DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG (in isoform J, isoform K and isoform N); 552..573; VSGRASFCGKRQQQQWPGRRHR -> MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH (in isoform J and isoform N)
3D Structural Models
Turn
351..353
Helix
211..225; 229..247; 252..267; 271..289; 294..309; 313..331; 336..350; 355..372; 378..394; 397..415; 426..435; 463..477; 480..494
Beta Strand
203..205; 249..251
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
155..176; Basic and acidic residues; 188..203; Low complexity
Repeat
213..246; TPR 1; 255..288; TPR 2; 297..330; TPR 3; 339..372; TPR 4; 381..414; TPR 5; 464..497; TPR 6
Coiled Coil
27..156
Region
155..203; Disordered; 553..573; Disordered
Protein Families
Kinesin light chain family
Sequence Similarities
Belongs to the kinesin light chain family.
Clinical Relevance
Interaction Protein
ENSG00000108953ENSG00000128245ENSG00000134308ENSG00000137171ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000170759ENSG00000174996
Interaction Count
9
Interaction Dataset
biogrid_opencellintact_biogrid_opencell