Protein detail
NEXN
Nexilin (F-actin-binding protein) (Nelin)
Protein symbol NEXN | UniProt ID | EVMP score 0.60 |
Frequency 12 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Nexilin (F-actin-binding protein) (Nelin)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
NELINnexilin
Gene Description
Nexilin F-actin binding protein
Chromosome
1
Position
77888513-77943895
Frequency
12
EVMP Score
0.60
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
675
Mass
80,658
Sequence
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0ZGT2-1; Sequence=Displayed; Name=2; IsoId=Q0ZGT2-2; Sequence=VSP_052541, VSP_052543; Name=3; IsoId=Q0ZGT2-3; Sequence=VSP_052542; Name=4; IsoId=Q0ZGT2-4; Sequence=VSP_043439
Alternative Sequence
9..72; Missing (in isoform 4); 150..163; Missing (in isoform 2); 237..298; Missing (in isoform 3); 673..675; SKN -> TDDY (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
27..66; Basic and acidic residues
Domain (FT)
582..670; Ig-like
Region
1..66; Disordered; 105..127; Disordered; 254..278; Disordered; 313..336; Disordered; 487..513; Disordered; 551..584; Disordered