Protein detail

NEXN

Nexilin (F-actin-binding protein) (Nelin)

Entry name NEXN	UniProt ID Q0ZGT2	EVMP confidence score 0.60
Supporting publications (n) 12	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Nexilin (F-actin-binding protein) (Nelin)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Ensembl

ENSG00000162614

Entrez Gene Symbol

NEXN

Gene Synonym (2)

NELINnexilin

Gene Description

Nexilin F-actin binding protein

Chromosome

Position

77888513-77943895

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization4

Tissue SpecificepididymisCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell

Function & Pathway5

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (4)

Biological Process (3)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
actin_regulation_adhesome	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CPVL CYB5R3 FBXO34 NEXN	P00387 Q0ZGT2 Q9H3G5 Q9NWN3	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	6	28211531 33169421 25776846 22808001 28240915 30232403

Sequence, Structure & Domains8

Sequences

Length

675

Mass

80,658

Sequence

MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0ZGT2-1; Sequence=Displayed; Name=2; IsoId=Q0ZGT2-2; Sequence=VSP_052541, VSP_052543; Name=3; IsoId=Q0ZGT2-3; Sequence=VSP_052542; Name=4; IsoId=Q0ZGT2-4; Sequence=VSP_043439

Alternative Sequence

9..72; Missing (in isoform 4); 150..163; Missing (in isoform 2); 237..298; Missing (in isoform 3); 673..675; SKN -> TDDY (in isoform 2)

Domain & Motif Annotations

Compositional Bias

27..66; Basic and acidic residues

Domain (FT)

582..670; Ig-like

Region

1..66; Disordered; 105..127; Disordered; 254..278; Disordered; 313..336; Disordered; 487..513; Disordered; 551..584; Disordered

Clinical Relevance5

Disease Involvement (2)

CardiomyopathyDisease variant

Antibody (2)

HPA011185 HPA011904

Interaction Protein

ENSG00000106066

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications12

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
36398564	Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available

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