Protein detail

NEXN

Nexilin (F-actin-binding protein) (Nelin)

Entry name
NEXN
UniProt ID
Q0ZGT2
EVMP confidence score
0.60
Supporting publications (n)
12
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
Nexilin (F-actin-binding protein) (Nelin)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
  • Predicted intracellular proteins
Ensembl
ENSG00000162614
Entrez Gene Symbol
NEXN
Gene Synonym (2)
NELINnexilin
Gene Description
Nexilin F-actin binding protein
Chromosome
1
Position
77888513-77943895
Supporting publications (n)
12
EVMP confidence score
0.60
Fluorescence & Localization
NEXN fluorescence
Tissue SpecificepididymisCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
  • Predicted intracellular proteins
Cellular Component (6)
Molecular Function (4)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
actin_regulation_adhesomeintracellular_intercellular_relatedAdhesomeYes
intracellular_intercellular_relatedintracellular_intercellular_relatedOmniPathYes

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CPVLCYB5R3FBXO34NEXNP00387Q0ZGT2Q9H3G5Q9NWN30:0:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry6282115313316942125776846228080012824091530232403
Sequence, Structure & Domains

Sequences

Length
675
Mass
80,658
Sequence
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0ZGT2-1; Sequence=Displayed; Name=2; IsoId=Q0ZGT2-2; Sequence=VSP_052541, VSP_052543; Name=3; IsoId=Q0ZGT2-3; Sequence=VSP_052542; Name=4; IsoId=Q0ZGT2-4; Sequence=VSP_043439
Alternative Sequence
9..72; Missing (in isoform 4); 150..163; Missing (in isoform 2); 237..298; Missing (in isoform 3); 673..675; SKN -> TDDY (in isoform 2)

Domain & Motif Annotations

Compositional Bias
27..66; Basic and acidic residues
Domain (FT)
582..670; Ig-like
Region
1..66; Disordered; 105..127; Disordered; 254..278; Disordered; 313..336; Disordered; 487..513; Disordered; 551..584; Disordered
Clinical Relevance
Disease Involvement (2)
CardiomyopathyDisease variant
Related Diseases
Cardiomyopathy
Antibody (2)
HPA011185HPA011904
Interaction Protein
ENSG00000106066
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications12
PMIDTitleRelated sentences
27894104Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.No related sentences available
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No related sentences available
29148239Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.No related sentences available
30646616Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No related sentences available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No related sentences available
34186243A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.No related sentences available
34817906Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.No related sentences available
36398564Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.No related sentences available
37786918Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.No related sentences available
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