Protein detail
NEXN
Nexilin (F-actin-binding protein) (Nelin)
Entry name NEXN | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 12 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Nexilin (F-actin-binding protein) (Nelin)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
NELINnexilin
Gene Description
Nexilin F-actin binding protein
Chromosome
1
Position
77888513-77943895
Supporting publications (n)
12
EVMP confidence score
0.60
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (4)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence8
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
675
Mass
80,658
Sequence
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0ZGT2-1; Sequence=Displayed; Name=2; IsoId=Q0ZGT2-2; Sequence=VSP_052541, VSP_052543; Name=3; IsoId=Q0ZGT2-3; Sequence=VSP_052542; Name=4; IsoId=Q0ZGT2-4; Sequence=VSP_043439
Alternative Sequence
9..72; Missing (in isoform 4); 150..163; Missing (in isoform 2); 237..298; Missing (in isoform 3); 673..675; SKN -> TDDY (in isoform 2)
Domain & Motif Annotations
Compositional Bias
27..66; Basic and acidic residues
Domain (FT)
582..670; Ig-like
Region
1..66; Disordered; 105..127; Disordered; 254..278; Disordered; 313..336; Disordered; 487..513; Disordered; 551..584; Disordered
Clinical Relevance
Disease Involvement (2)
CardiomyopathyDisease variant
Related Diseases
Interaction Protein
ENSG00000106066
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications12
| PMID | Title | Related sentences |
|---|---|---|
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No related sentences available |
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