Protein detail
BST2
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
Entry name BST2 | UniProt ID | EVMP score 0.38 |
Frequency 9 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
Protein Class
CD markersPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- CD markers
Transmembrane
21..48; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BST-2CD317HM1.24tetherin
Gene Description
Bone marrow stromal cell antigen 2
Chromosome
19
Position
17402939-17405630
Frequency
9
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificEndometrial secretory cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- CD markers
Cellular Component
- GO:0005737 cytoplasm
- GO:0005771 multivesicular body
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0035577 azurophil granule membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045121 membrane raft
- GO:0070062 extracellular exosome
- GO:0098552 side of membrane
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-909733 interferon alpha beta signaling
- R-hsa-913531 interferon signaling
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9692916 sars cov 1 activates modulates innate immune responses
- R-hsa-9692914 sars cov 1 host interactions
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | Yes |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | Yes |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | Yes |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | Yes |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | Yes |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | Yes |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | Yes |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | Yes |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | Yes |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
180
Mass
19,769
Sequence
MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAVMECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ
Alternative Products
Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=l-Tetherin; IsoId=Q10589-1; Sequence=Displayed; Name=2; Synonyms=s-Tetherin; IsoId=Q10589-2; Sequence=VSP_053250
Alternative Sequence
1..12; Missing (in isoform 2)
3D Structural Models
Helix
52..148
Beta Strand
25..28; 152..154
3D Structure
Electron microscopy (5); NMR spectroscopy (1); X-ray crystallography (9)
Domain & Motif Annotations
Coiled Coil
68..152
Domain (CC)
The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading.
Protein Families
Tetherin family
Sequence Similarities
Belongs to the tetherin family.
Clinical Relevance
Drug Targets
Literature-reported target
Drugs