Protein detail
BST2
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
Entry name BST2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 9 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
Protein Class (4)
CD markersPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- CD markers
Transmembrane
21..48; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
BST-2CD317HM1.24tetherin
Gene Description
Bone marrow stromal cell antigen 2
Chromosome
19
Position
17402939-17405630
Supporting publications (n)
9
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue Specificlymphoid tissueCell SpecificEndometrial secretory cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function (2)
- Transporters:Transporter channels and pores
- CD markers
Cellular Component (12)
- GO:0005737 cytoplasm
- GO:0005771 multivesicular body
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0035577 azurophil granule membrane
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045121 membrane raft
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Molecular Function (5)
Biological Process (3)
KEGG (3)
Reactome (11)
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-909733 interferon alpha beta signaling
- R-hsa-913531 interferon signaling
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9692916 sars cov 1 activates modulates innate immune responses
- R-hsa-9692914 sars cov 1 host interactions
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9679506 sars cov infections
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence43
Ligand-Receptor Signaling (40)
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| peripheral | peripheral | UniProt_location | No | No | No | Yes | Yes |
| peripheral | peripheral | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | Yes |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | Yes | Yes |
Protein Complex Composition (2)
Sequence, Structure & Domains12
Sequences
Length
180
Mass
19,769
Sequence
MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAVMECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ
Alternative Products
Event=Alternative initiation; Named isoforms=2; Name=1; Synonyms=l-Tetherin; IsoId=Q10589-1; Sequence=Displayed; Name=2; Synonyms=s-Tetherin; IsoId=Q10589-2; Sequence=VSP_053250
Alternative Sequence
1..12; Missing (in isoform 2)
3D Structural Models
Helix
52..148
Beta Strand
25..28; 152..154
3D Structure
Electron microscopy (5); NMR spectroscopy (1); X-ray crystallography (9)
Domain & Motif Annotations
Coiled Coil
68..152
Domain (CC)
The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading.
Protein Families
Tetherin family
Sequence Similarities
Belongs to the tetherin family.
Clinical Relevance3
Drug Targets
Literature-reported target
Drugs (19)
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 26884841 | Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 34071777 | Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways. | No abstract available |
| 38644352 | The tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment. | No abstract available |
| 39436214 | Human ovarian extracellular vesicles proteome from polycystic ovary syndrome patients associate with follicular development alterations. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |