Protein detail
FUT2
Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
Entry name FUT2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Blood group antigen proteinsEnzymesMetabolic proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
Protein Class (4)
Blood group antigen proteinsEnzymesMetabolic proteinsPredicted membrane proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Blood group antigen proteins
- Enzymes
Transmembrane
15..28; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
SESe2SEC2sej
Gene Description
Fucosyltransferase 2
Chromosome
19
Position
48695971-48705951
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificEarly spermatidsBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (3)
- ENZYME proteins:Transferases
- Blood group antigen proteins
- Enzymes
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (6)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence21
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane_predicted | transmembrane | OmniPath | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | OmniPath |
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Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DENRFKBP3MCTS1POFUT2POLDIP3SYAP1TCEA1 | O43583P23193Q00688Q96A49Q9BY77Q9ULC4Q9Y2G5 | 0:0:0:0:0:0:0 | hu.MAP | |||
| DENRFKBP3MCTS1POFUT2TCEA1 | O43583P23193Q00688Q9ULC4Q9Y2G5 | 0:0:0:0:0 | hu.MAP | |||
| DENRDNMT1DOCK11MCTS1POFUT2 | O43583P26358Q5JSL3Q9ULC4Q9Y2G5 | 0:0:0:0:0 | hu.MAP2 | |||
| DENRDOCK11MCTS1POFUT2 | O43583Q5JSL3Q9ULC4Q9Y2G5 | 0:0:0:0 | hu.MAP2 | |||
| DNAJC17FKBP3MCTS1POFUT2TCEA1 | P23193Q00688Q9NVM6Q9ULC4Q9Y2G5 | 0:0:0:0:0 | hu.MAP | |||
| MCTS1POFUT2 | Q9ULC4Q9Y2G5 | 0:0 | hu.MAP2 | |||
| POFUT2 | Q9Y2G5 | 2 | PDB | PDB:4ap6PDB:4ap5 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass Spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
343
Mass
39,017
Sequence
MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH
Domain & Motif Annotations
Protein Families
Glycosyltransferase 11 family
Sequence Similarities
Belongs to the glycosyltransferase 11 family.
Clinical Relevance
Drugs
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No related sentences available |