Protein detail

FUT2

Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)

Entry name FUT2	UniProt ID Q10981	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Blood group antigen proteinsEnzymesMetabolic proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (4)

Blood group antigen proteinsEnzymesMetabolic proteinsPredicted membrane proteins

Protein Function (3)

ENZYME proteins:Transferases
Blood group antigen proteins
Enzymes

Transmembrane

15..28; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000176920

Entrez Gene Symbol

FUT2

Gene Synonym (4)

SESe2SEC2sej

Gene Description

Fucosyltransferase 2

Chromosome

Position

48695971-48705951

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificbone marrowCell SpecificEarly spermatidsBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function (3)

ENZYME proteins:Transferases
Blood group antigen proteins
Enzymes

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (6)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence21

Ligand-Receptor Signaling (13)

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Protein Complex Composition (7)

7 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DENR FKBP3 MCTS1 POFUT2 POLDIP3 SYAP1 TCEA1	O43583 P23193 Q00688 Q96A49 Q9BY77 Q9ULC4 Q9Y2G5	0:0:0:0:0:0:0	hu.MAP
DENR FKBP3 MCTS1 POFUT2 TCEA1	O43583 P23193 Q00688 Q9ULC4 Q9Y2G5	0:0:0:0:0	hu.MAP
DENR DNMT1 DOCK11 MCTS1 POFUT2	O43583 P26358 Q5JSL3 Q9ULC4 Q9Y2G5	0:0:0:0:0	hu.MAP2
DENR DOCK11 MCTS1 POFUT2	O43583 Q5JSL3 Q9ULC4 Q9Y2G5	0:0:0:0	hu.MAP2
DNAJC17 FKBP3 MCTS1 POFUT2 TCEA1	P23193 Q00688 Q9NVM6 Q9ULC4 Q9Y2G5	0:0:0:0:0	hu.MAP
MCTS1 POFUT2	Q9ULC4 Q9Y2G5	0:0	hu.MAP2
POFUT2	Q9Y2G5	2	PDB	PDB:4ap6PDB:4ap5

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass Spectrometry	1	32384937

Sequence, Structure & Domains5

Sequences

Length

343

Mass

39,017

Sequence

MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH

Domain & Motif Annotations

Protein Families

Glycosyltransferase 11 family

Sequence Similarities

Belongs to the glycosyltransferase 11 family.

Clinical Relevance2

Drugs

DEHYDRATED ALCOHOL

Antibody

HPA014402

Supporting Publications1

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available