Protein detail

ZP4

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Entry name ZP4	UniProt ID Q12836	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Protein Class (2)

Predicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Transmembrane

506..526; Helical

Transmembrane Count

Ensembl

ENSG00000116996

Entrez Gene Symbol

ZP4

Gene Synonym (3)

ZP1BZPBZPB2

Gene Description

Zona pellucida glycoprotein 4

Chromosome

Position

237877864-237890922

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Cell SpecificCardiomyocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificnaive B-cell

Function & Pathway6

Protein Function

Predicted secreted proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Reactome (3)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence35

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	No
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	No
secreted	secreted	HPA_secretome	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
glycoprotein	ecm	Matrisome	Yes	No	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
TREX transcription-export complexDX39A variant	ALYREF CHTOP DDX39A ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O00148 O75152 P82979 P84090 Q13769 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-28950645	33191911 14755292
TREX transcription-export complexDX39B variant	ALYREF CHTOP DDX39B ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O75152 P82979 P84090 Q13769 Q13838 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:7APKintact:EBI-9017767PDB:7ZNK	37020021 14755292 33191911

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	39247822

Sequence, Structure & Domains7

Sequences

Length

540

Mass

59,400

Sequence

MWLLRCVLLCVSLSLAVSGQHKPEAPDYSSVLHCGPWSFQFAVNLNQEATSPPVLIAWDNQGLLHELQNDSDCGTWIRKGPGSSVVLEATYSSCYVTEWDSHYIMPVGVEGAGAAEHKVVTERKLLKCPMDLLARDAPDTDWCDSIPARDRLPCAPSPISRGDCEGLGCCYSSEEVNSCYYGNTVTLHCTREGHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAFVLFQFPFTSCGTTRQITGDRAVYENELVATRDVKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPINVQVFTLPPPFPETQPGPLTLELQIAKDKNYGSYYGVGDYPVVKLLRDPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVQKALDLPFPSHHQRFSIFTFSFVNPTVEKQALRGPVHLHCSVSVCQPAETPSCVVTCPDLSRRRNFDNSSQNTTASVSSKGPMILLQATKDPPEKLRVPVDSKVLWVAGLSGTLILGALLVSYLAVKKQKSCPDQMCQ

Domain & Motif Annotations

Domain (CC)

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Domain (FT)

141..183; P-type; 188..466; ZP

Protein Families (2)

ZP domain family
ZPB subfamily

Sequence Similarities

Belongs to the ZP domain family. ZPB subfamily.

Clinical Relevance1

Antibody

HPA008547

Supporting Publications1

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available