Protein detail

ZP4

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Entry name ZP4	UniProt ID Q12836	EVMP confidence score 0.28
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteinsPredicted secreted proteins

Basic Information

Protein Names

Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

Protein Class (2)

Predicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Transmembrane

506..526; Helical

Transmembrane Count

Ensembl

ENSG00000116996

Entrez Gene Symbol

ZP4

Gene Synonym (3)

ZP1BZPBZPB2

Gene Description

Zona pellucida glycoprotein 4

Chromosome

Position

237877864-237890922

Supporting publications (n)

EVMP confidence score

0.28

Fluorescence & Localization

Cell SpecificCardiomyocytesSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificnaive B-cell

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Reactome (3)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence35

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009			Yes	Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009			Yes	Yes

Page 4 of 4Previous

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
TREX transcription-export complexDX39A variant	ALYREF CHTOP DDX39A ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O00148 O75152 P82979 P84090 Q13769 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-28950645	33191911 14755292
TREX transcription-export complexDX39B variant	ALYREF CHTOP DDX39B ERH FYTTD1 LUZP4 NCBP3 POLDIP3 SARNP THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 ZC3H11A	O75152 P82979 P84090 Q13769 Q13838 Q53F19 Q6I9Y2 Q86V81 Q86W42 Q8NI27 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9P127 Q9Y3Y2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:7APKintact:EBI-9017767PDB:7ZNK	37020021 14755292 33191911

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	39247822

Sequence, Structure & Domains

Sequences

Length

540

Mass

59,400

Sequence

MWLLRCVLLCVSLSLAVSGQHKPEAPDYSSVLHCGPWSFQFAVNLNQEATSPPVLIAWDNQGLLHELQNDSDCGTWIRKGPGSSVVLEATYSSCYVTEWDSHYIMPVGVEGAGAAEHKVVTERKLLKCPMDLLARDAPDTDWCDSIPARDRLPCAPSPISRGDCEGLGCCYSSEEVNSCYYGNTVTLHCTREGHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAFVLFQFPFTSCGTTRQITGDRAVYENELVATRDVKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPINVQVFTLPPPFPETQPGPLTLELQIAKDKNYGSYYGVGDYPVVKLLRDPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVQKALDLPFPSHHQRFSIFTFSFVNPTVEKQALRGPVHLHCSVSVCQPAETPSCVVTCPDLSRRRNFDNSSQNTTASVSSKGPMILLQATKDPPEKLRVPVDSKVLWVAGLSGTLILGALLVSYLAVKKQKSCPDQMCQ

Domain & Motif Annotations

Domain (CC)

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Domain (FT)

141..183; P-type; 188..466; ZP

Protein Families (2)

ZP domain family
ZPB subfamily

Sequence Similarities

Belongs to the ZP domain family. ZPB subfamily.

Clinical Relevance

Antibody

HPA008547

Supporting Publications1

PMID	Title	Related sentences
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available