Protein detail
HYAL2
Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)
Protein symbol HYAL2 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
LuCa-2LUCA2
Gene Description
Hyaluronidase 2
Chromosome
3
Position
50317790-50322782
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0030139 endocytic vesicle
- GO:0031410 cytoplasmic vesicle
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function
- GO:0001618 virus receptor activity
- GO:0003713 transcription coactivator activity
- GO:0004415 hyalurononglucosaminidase activity
- GO:0005515 protein binding
- GO:0005540 hyaluronic acid binding
- GO:0019899 enzyme binding
- GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity
- GO:0030971 receptor tyrosine kinase binding
- GO:0033906 hyaluronoglucuronidase activity
- GO:0050431 transforming growth factor beta binding
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | No | Yes |
| receptor | receptor | OmniPath | No | Yes | No | No | Yes |
| extracellular | extracellular | DGIdb | No | No | No | No | Yes |
| extracellular | extracellular | LOCATE | No | No | No | No | Yes |
| extracellular | extracellular | OmniPath | No | No | No | No | Yes |
| intracellular | intracellular | ComPPI | No | No | No | No | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | No | Yes |
| intracellular | intracellular | OmniPath | No | No | No | No | Yes |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | No | No | Yes |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | No | No | Yes |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HYAL2 | Q12891 | SMAD4 | Q13485 | Yes | Yes | No | SignaLink3 | SignaLink3:23331499SignaLink3:20542955 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DHFR2ERFEHYAL2ST3GAL4TAFAZZINVWDE | Q11206Q12891Q16635Q4G0M1Q86XF0Q8N2E2 | 0:0:0:0:0:0 | hu.MAP | |||
| DHFR2ERFEHYAL2TAFAZZIN | Q12891Q16635Q4G0M1Q86XF0 | 0:0:0:0 | hu.MAP | |||
| DHFR2DPEP2ERFEHYAL2TAFAZZINVWDE | Q12891Q16635Q4G0M1Q86XF0Q8N2E2Q9H4A9 | 0:0:0:0:0:0 | hu.MAP | |||
| DPEP2DPEP3HYAL2LRFN3 | Q12891Q9BTN0Q9H4A9Q9H4B8 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
473
Mass
53,860
Sequence
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
3D Structural Models
Domain & Motif Annotations
Domain (FT)
361..439; EGF-like
Protein Families
Glycosyl hydrolase 56 family
Sequence Similarities
Belongs to the glycosyl hydrolase 56 family.