Protein detail
HYAL2
Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)
Entry name HYAL2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)
Protein Class (4)
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
LuCa-2LUCA2
Gene Description
Hyaluronidase 2
Chromosome
3
Position
50317790-50322782
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization1
Cell SpecificCardiomyocytes
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (15)
- GO:0000139 Golgi membrane
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
Page 1 of 2
Molecular Function (10)
- GO:0001618 virus receptor activity
- GO:0003713 transcription coactivator activity
- GO:0004415 hyalurononglucosaminidase activity
- GO:0005515 protein binding
- GO:0005540 hyaluronic acid binding
- GO:0019899 enzyme binding
- GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity
- GO:0030971 receptor tyrosine kinase binding
- GO:0033906 hyaluronoglucuronidase activity
- GO:0050431 transforming growth factor beta binding
Biological Process (3)
KEGG (3)
Reactome (4)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence25
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| hyaluronidase | cell_surface_enzyme | OmniPath | Yes | No | No | No | Yes |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | No | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | No | Yes |
| receptor | receptor | CellCellInteractions | No | Yes | No | No | Yes |
Page 2 of 2Previous
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HYAL2 | Q12891 | SMAD4 | Q13485 | Yes | Yes | No | SignaLink3 | SignaLink3:23331499SignaLink3:20542955 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DHFR2ERFEHYAL2ST3GAL4TAFAZZINVWDE | Q11206Q12891Q16635Q4G0M1Q86XF0Q8N2E2 | 0:0:0:0:0:0 | hu.MAP | |||
| DHFR2ERFEHYAL2TAFAZZIN | Q12891Q16635Q4G0M1Q86XF0 | 0:0:0:0 | hu.MAP | |||
| DHFR2DPEP2ERFEHYAL2TAFAZZINVWDE | Q12891Q16635Q4G0M1Q86XF0Q8N2E2Q9H4A9 | 0:0:0:0:0:0 | hu.MAP | |||
| DPEP2DPEP3HYAL2LRFN3 | Q12891Q9BTN0Q9H4A9Q9H4B8 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains6
Sequences
Length
473
Mass
53,860
Sequence
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
Domain & Motif Annotations
Domain (FT)
361..439; EGF-like
Protein Families
Glycosyl hydrolase 56 family
Sequence Similarities
Belongs to the glycosyl hydrolase 56 family.
Clinical Relevance3
Disease Involvement
Disease variant
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 39408670 | Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles. | No abstract available |
| 40596376 | Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. | No abstract available |