Protein detail

STRN3

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Protein symbol STRN3	UniProt ID Q13033	EVMP score 0.88
Frequency 36	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000196792

Entrez Gene Symbol

STRN3

Gene Synonym

PPP2R6BS/G2NASG2NA

Gene Description

Striatin 3

Chromosome

Position

30893799-31026401

Frequency

EVMP Score

0.88

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

23 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PP2A A/C-SG2NA complex	PPP2CA PPP2R1A STRN3	P30153 P67775 Q13033	0:0:0	CORUM	CORUM:6183	10681496
STRIPAK complexSTRIP1-STRN3 variant	MOB4 PPP2CA PPP2R1A STRIP1 STRN3	P30153 P67775 Q13033 Q5VSL9 Q9Y3A3	1:1:4:1:1	ComplexPortalPDB	PDB:7k36intact:EBI-9010160PDB:7K36	14755292 33633399
STRIPAK complexSTRIP2-STRN3 variant	MOB4 PPP2CA PPP2R1A STRIP2 STRN3	P30153 P67775 Q13033 Q9ULQ0 Q9Y3A3	1:1:4:1:1	ComplexPortal	intact:EBI-48424666	14755292 33633399
protein phosphatase type 2A complex	CYCS PPP2CA PPP2CB PPP2R1A PPP2R2A PPP2R2B PPP2R2C PPP2R2D PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPA STRN STRN3 STRN4	O43815 P30153 P62714 P63151 P67775 P99999 Q00005 Q06190 Q13033 Q13362 Q14738 Q15172 Q15173 Q15257 Q16537 Q66LE6 Q9NRL3 Q9Y2T4 Q9Y5P8	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC682	10318862 10945473 17174897 8206937 1849734 17245430 11007961 18782753 8703017 17055435
	BUB3 CCT2 CCT5 CCT6A CCT7 CCT8 CDC5L HDAC1 IGBP1 PPP2R1A PPP2R2D STRN3 TCP1	O43684 P17987 P30153 P40227 P48643 P50990 P78318 P78371 Q13033 Q13547 Q66LE6 Q99459 Q99832	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4442
	CCT3 CCT5 CCT6A CCT7 CCT8 PPP2CA PPP2CB PPP2R2A PPP2R2C PPP2R2D PRH2 PRKAB2 STRN3 STRN4 TCP1	O43741 P02810 P17987 P40227 P48643 P49368 P50990 P62714 P63151 P67775 Q13033 Q66LE6 Q99832 Q9NRL3 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7448
	CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 MOB4 PPP2CA PPP2CB PPP2R2A PPP2R2D STK24 STRN STRN3 TCP1 UBC	O43815 P0CG48 P17987 P40227 P48643 P49368 P50990 P50991 P62714 P63151 P67775 P78371 Q13033 Q66LE6 Q99832 Q9Y3A3 Q9Y6E0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC8865
	MOB4 SLMAP STRIP1 STRN STRN3 STRN4	O43815 Q13033 Q14BN4 Q5VSL9 Q9NRL3 Q9Y3A3	0:0:0:0:0:0	hu.MAP2
	AHSA1 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 PPP2CA PPP2CB PPP2R2A PPP2R2D STK24 STRN3 STRN4 TCP1	O95433 P17987 P40227 P48643 P49368 P50990 P50991 P62714 P63151 P67775 Q13033 Q66LE6 Q99832 Q9NRL3 Q9Y6E0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4949
	CAD CCT3 CCT5 CCT6A CCT7 CCT8 PPP2CA PPP2CB PPP2R2A PPP2R2B PPP2R2C PPP2R2D STRN3 STRN4 TCP1	P17987 P27708 P40227 P48643 P49368 P50990 P62714 P63151 P67775 Q00005 Q13033 Q66LE6 Q99832 Q9NRL3 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5461

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingMass spectrometry	1	30550287

Sequence, Structure & Domains

Sequences

Length

797

Mass

87,209

Sequence

MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Beta; IsoId=Q13033-1; Sequence=Displayed; Name=Alpha; IsoId=Q13033-2; Sequence=VSP_006786

Alternative Sequence

330..413; Missing (in isoform Alpha)

3D Structural Models

Turn

710..712; 743..745

Helix

86..129; 175..185; 575..577

Beta Strand

471..476; 485..488; 490..498; 500..502; 504..508; 526..528; 538..541; 545..551; 555..561; 569..571; 578..583; 589..594; 601..605; 610..613; 623..625; 637..639; 647..650; 652..654; 656..659; 661..663; 668..670; 684..689; 691..700; 703..709; 717..720; 726..731; 735..742; 747..753; 758..761; 774..777; 779..781; 784..787; 793..797

3D Structure

Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

1..13; Gly residues; 23..43; Gly residues; 44..56; Low complexity; 230..241; Basic and acidic residues; 253..265; Acidic residues

Repeat

478..517; WD 1; 531..570; WD 2; 584..623; WD 3; 679..718; WD 4; 721..760; WD 5; 767..797; WD 6

Coiled Coil

77..136

Region

1..60; Disordered; 71..79; Caveolin-binding; 166..183; Calmodulin-binding; 224..278; Disordered; 313..338; Disordered

Protein Families

WD repeat striatin family

Sequence Similarities

Belongs to the WD repeat striatin family.

Clinical Relevance

Antibody

HPA003392 HPA004636 CAB069925

Interaction Protein

ENSG00000009790ENSG00000052723ENSG00000071054ENSG00000077063ENSG00000088986ENSG00000090372ENSG00000101109ENSG00000102572ENSG00000104695ENSG00000105568ENSG00000111790ENSG00000113575ENSG00000115694ENSG00000115808ENSG00000134602ENSG00000143079ENSG00000143093ENSG00000154310ENSG00000163681ENSG00000264364

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencellintact_biogrid_opencell