Protein detail
STRN3
Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)
Entry name STRN3 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 36 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
PPP2R6BS/G2NASG2NA
Gene Description
Striatin 3
Chromosome
14
Position
30893799-31026401
Supporting publications (n)
36
EVMP confidence score
0.88
Fluorescence & Localization4
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (10)
Molecular Function (7)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence29
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (23)
23 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blottingMass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains15
Sequences
Length
797
Mass
87,209
Sequence
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Beta; IsoId=Q13033-1; Sequence=Displayed; Name=Alpha; IsoId=Q13033-2; Sequence=VSP_006786
Alternative Sequence
330..413; Missing (in isoform Alpha)
3D Structural Models
Turn
710..712; 743..745
Helix
86..129; 175..185; 575..577
Beta Strand
471..476; 485..488; 490..498; 500..502; 504..508; 526..528; 538..541; 545..551; 555..561; 569..571; 578..583; 589..594; 601..605; 610..613; 623..625; 637..639; 647..650; 652..654; 656..659; 661..663; 668..670; 684..689; 691..700; 703..709; 717..720; 726..731; 735..742; 747..753; 758..761; 774..777; 779..781; 784..787; 793..797
3D Structure
Electron microscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1..13; Gly residues; 23..43; Gly residues; 44..56; Low complexity; 230..241; Basic and acidic residues; 253..265; Acidic residues
Repeat
478..517; WD 1; 531..570; WD 2; 584..623; WD 3; 679..718; WD 4; 721..760; WD 5; 767..797; WD 6
Coiled Coil
77..136
Region
1..60; Disordered; 71..79; Caveolin-binding; 166..183; Calmodulin-binding; 224..278; Disordered; 313..338; Disordered
Protein Families
WD repeat striatin family
Sequence Similarities
Belongs to the WD repeat striatin family.
Clinical Relevance4
Interaction Protein (20)
ENSG00000009790ENSG00000052723ENSG00000071054ENSG00000077063ENSG00000088986ENSG00000090372ENSG00000101109ENSG00000102572ENSG00000104695ENSG00000105568ENSG00000111790ENSG00000113575ENSG00000115694ENSG00000115808ENSG00000134602ENSG00000143079ENSG00000143093ENSG00000154310ENSG00000163681ENSG00000264364
Interaction Count
20
Interaction Dataset (3)
intact_biogridbiogrid_opencellintact_biogrid_opencell
Supporting Publications36
| PMID | Title | Abstract |
|---|---|---|
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No abstract available |
| 34622320 | A possible role of gas-phase electrophoretic mobility molecular analysis (nES GEMMA) in extracellular vesicle research. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 36398564 | Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |