Protein detail
TRDN
Triadin
Entry name TRDN | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Triadin
Protein Class (7)
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Transmembrane
48..68; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TRISK
Gene Description
Triadin
Chromosome
6
Position
123216339-123637093
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificbrainCell SpecificEndometrial stromal cells
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Cellular Component (10)
- GO:0005654 nucleoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0014701 junctional sarcoplasmic reticulum membrane
- GO:0016020 membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0030314 junctional membrane complex
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0033018 sarcoplasmic reticulum lumen
Molecular Function (4)
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence16
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
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Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
729
Mass
81,595
Sequence
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13061-1; Sequence=Displayed; Name=2; IsoId=Q13061-2; Sequence=VSP_045563, VSP_045564, VSP_045565; Name=3; IsoId=Q13061-3; Sequence=VSP_045561, VSP_045562
Alternative Sequence
162..167; VTHKEK -> EVGHSS (in isoform 3); 168..729; Missing (in isoform 3); 265..284; Missing (in isoform 2); 311..317; EKEGEKK -> GKYFFFS (in isoform 2); 318..729; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
8..24; Polar residues; 117..129; Acidic residues; 130..265; Basic and acidic residues; 309..357; Basic and acidic residues; 371..433; Basic and acidic residues; 444..509; Basic and acidic residues; 516..531; Basic and acidic residues; 538..562; Basic and acidic residues; 580..598; Basic and acidic residues; 609..674; Basic and acidic residues; 715..729; Polar residues
Region
1..28; Disordered; 117..265; Disordered; 281..682; Disordered; 705..729; Disordered
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |