Protein detail
TRDN
Triadin
Entry name TRDN | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Triadin
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Transmembrane
48..68; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TRISK
Gene Description
Triadin
Chromosome
6
Position
123216339-123637093
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificEndometrial stromal cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Cellular Component
- GO:0005654 nucleoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0014701 junctional sarcoplasmic reticulum membrane
- GO:0016020 membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0030314 junctional membrane complex
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0033018 sarcoplasmic reticulum lumen
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
729
Mass
81,595
Sequence
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13061-1; Sequence=Displayed; Name=2; IsoId=Q13061-2; Sequence=VSP_045563, VSP_045564, VSP_045565; Name=3; IsoId=Q13061-3; Sequence=VSP_045561, VSP_045562
Alternative Sequence
162..167; VTHKEK -> EVGHSS (in isoform 3); 168..729; Missing (in isoform 3); 265..284; Missing (in isoform 2); 311..317; EKEGEKK -> GKYFFFS (in isoform 2); 318..729; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
8..24; Polar residues; 117..129; Acidic residues; 130..265; Basic and acidic residues; 309..357; Basic and acidic residues; 371..433; Basic and acidic residues; 444..509; Basic and acidic residues; 516..531; Basic and acidic residues; 538..562; Basic and acidic residues; 580..598; Basic and acidic residues; 609..674; Basic and acidic residues; 715..729; Polar residues
Region
1..28; Disordered; 117..265; Disordered; 281..682; Disordered; 705..729; Disordered