EV MemProt Atlas

Basic Information

Protein Names

Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]

Protein Class

CD markersPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Transmembrane

206..228; Helical

Transmembrane Count

1

Ensembl

ENSG00000134470

Entrez Gene Symbol

IL15RA

Gene Synonym

CD215IL-15RA

Gene Description

Interleukin 15 receptor subunit alpha

Chromosome

10

Position

5943639-5978187

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL15RA	SYK	P43405	Y	227	phosphorylation	SIGNOR_ProtMapperKEASIGNORProtMapper	SIGNOR:11714793 ProtMapper:11714793 KEA:11714793
IL15RA	SYK	P43405	Y	191	phosphorylation	KEA	KEA:11714793

Ligand-Receptor Signaling

68 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	UniProt_location	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No
transmembrane	transmembrane	LOCATE	No	No	Yes	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL15	P40933	I15RA	Q13261	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	HINT:16284400 Guide2Pharma:19710453 SPIKE_LC:17145710 connectomeDB2020:16284400 connectomeDB2020:15265897 Baccin2019:15265897 Lit-BM-17:10903799 HPRD:7641685 CellTalkDB:15265897 SIGNOR:17709786 HPRD:16284400 InnateDB:16284400 HPMR:15265897 Baccin2019:7641685 HINT:17643103 LRdb:7641685 connectomeDB2020:7641685 SignaLink3:23331499 SignaLink3:8530383 Lit-BM-17:16284400 Baccin2019:16284400 LRdb:16284400 IntAct:16284400 LRdb:15265897 HINT:23104097
I15RA	Q13261	JAK3	P52333	Yes	Yes	No	WangSIGNOR	SIGNOR:30029643
I15RA	Q13261	IL2RB	P14784	Yes	Yes	No	HPRDWangSIGNOR	HPRD:7641685 SIGNOR:17709786
I15RA	Q13261	JAK1	P23458	Yes	Yes	No	WangSIGNOR	SIGNOR:30029643
KSYK	P43405	I15RA	Q13261	Yes	Yes	No	MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	HPRD:11714793 SIGNOR:11714793 ProtMapper:11714793 KEA:11714793
I15RA	Q13261	TYK2	P29597	Yes	Yes	No	WangSIGNOR	SIGNOR:30029643

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL15 IL15RA	P40933 Q13261	2:2	PDB	PDB:2z3rPDB:2z3q

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Ultrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry [MALDI TOF]\|Mass spectrometry [QTOF]Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	12519789

Sequence, Structure & Domains

Sequences

Length

267

Mass

28,233

Sequence

MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL

Alternative Products

Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q13261-1; Sequence=Displayed; Name=2; Synonyms=delta3E1E7Il-15RA; IsoId=Q13261-3; Sequence=VSP_012625; Name=3; Synonyms=E1E7'Il-15RA; IsoId=Q13261-4; Sequence=VSP_012626; Name=4; Synonyms=delta3E1E7'Il-15RA; IsoId=Q13261-5; Sequence=VSP_012625, VSP_012626; Name=5; Synonyms=delta2E1E7Il-15RA; IsoId=Q13261-6; Sequence=VSP_012624; Name=6; Synonyms=delta2E1E7'Il-15RA; IsoId=Q13261-7; Sequence=VSP_012624, VSP_012626; Name=7; Synonyms=delta2deltaE1E73Il-15RA; IsoId=Q13261-8; Sequence=VSP_012623; Name=8; Synonyms=delta2delta3E1E7'Il-15RA; IsoId=Q13261-9; Sequence=VSP_012623, VSP_012626; Name=9; IsoId=Q13261-10; Sequence=VSP_055406

Alternative Sequence

1..36; Missing (in isoform 9); 30..127; Missing (in isoform 7 and isoform 8); 31..95; Missing (in isoform 5 and isoform 6); 95..128; RDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKE -> K (in isoform 2 and isoform 4); 232..267; QTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL -> ASVCSCHPRSAGHTCSVGSVC (in isoform 3, isoform 4, isoform 6 and isoform 8)

3D Structural Models

Turn

79..81

Helix

97..102

Beta Strand

42..44; 54..59; 63..65; 72..77; 84..86; 93..95

3D Structure

NMR spectroscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

108..124; Polar residues; 129..145; Low complexity; 152..165; Polar residues

Domain (FT)

31..95; Sushi

Region

102..178; Disordered

Clinical Relevance

Related Diseases

Acute myeloid leukaemia Bladder cancer Colorectal cancer Head and neck cancer Human immunodeficiency virus disease Lung cancer Malignant haematopoietic neoplasm Multiple myeloma Pancreatic cancer Solid tumour/cancer

Biomarker

Phase 2; Phase 1/2; Phase 1

Drugs

IL-15 ALT-803 RECOMBINANT HUMAN INTERLEUKIN-15 IL-2/9/15 GAMMA CHAIN RECEPTOR INHIBITOR BNZ-1

Antibody

CAB026215 HPA036245

Protein symbol I15RA	UniProt ID Q13261	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

I15RA