Protein detail
IFIT5
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
Entry name IFIT5 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 20 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RI58
Gene Description
Interferon induced protein with tetratricopeptide repeats 5
Chromosome
10
Position
89414568-89421605
Supporting publications (n)
20
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function (7)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M41 Pid er nongenomic pathway
- M12 Pid rhoa pathway
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence4
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Western blottingMass spectrometryMass spectrometry [QTOF] | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
482
Mass
55,847
Sequence
MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFLTALCELRLSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13325-1; Sequence=Displayed; Name=2; IsoId=Q13325-2; Sequence=VSP_056412
Alternative Sequence
158..205; Missing (in isoform 2)
3D Structural Models
Turn
304..306
Helix
3..15; 19..21; 26..28; 31..44; 50..63; 67..84; 86..88; 91..93; 94..106; 110..126; 138..150; 153..155; 156..169; 174..189; 201..210; 215..227; 231..244; 249..261; 265..278; 283..303; 310..333; 338..350; 354..365; 372..388; 393..406; 413..430; 435..447; 451..464; 469..480
Beta Strand
46..48; 130..133; 193..195; 408..410
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Repeat
51..84; TPR 1; 94..127; TPR 2; 138..173; TPR 3; 181..214; TPR 4; 249..282; TPR 5; 338..371; TPR 6; 376..410; TPR 7; 435..468; TPR 8
Domain (CC)
RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505, PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).
Region
254..260; Interaction with the 5'-triphosphate group of PPP-RNA
Protein Families
IFIT family
Sequence Similarities
Belongs to the IFIT family.
Supporting Publications20
| PMID | Title | Related sentences |
|---|---|---|
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No related sentences available |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 32886718 | Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics. | No related sentences available |
| 33729255 | A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles. | No related sentences available |
| 34071777 | Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways. | No related sentences available |
| 34681822 | Protein Cargo of Salivary Small Extracellular Vesicles as Potential Functional Signature of Oral Squamous Cell Carcinoma. | No related sentences available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No related sentences available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No related sentences available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
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