Protein detail
IFIT5
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
Entry name IFIT5 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 20 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RI58
Gene Description
Interferon induced protein with tetratricopeptide repeats 5
Chromosome
10
Position
89414568-89421605
Supporting publications (n)
20
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function (7)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M41 Pid er nongenomic pathway
- M12 Pid rhoa pathway
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence4
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Western blottingMass spectrometryMass spectrometry [QTOF] | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
482
Mass
55,847
Sequence
MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFLTALCELRLSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13325-1; Sequence=Displayed; Name=2; IsoId=Q13325-2; Sequence=VSP_056412
Alternative Sequence
158..205; Missing (in isoform 2)
3D Structural Models
Turn
304..306
Helix
3..15; 19..21; 26..28; 31..44; 50..63; 67..84; 86..88; 91..93; 94..106; 110..126; 138..150; 153..155; 156..169; 174..189; 201..210; 215..227; 231..244; 249..261; 265..278; 283..303; 310..333; 338..350; 354..365; 372..388; 393..406; 413..430; 435..447; 451..464; 469..480
Beta Strand
46..48; 130..133; 193..195; 408..410
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Repeat
51..84; TPR 1; 94..127; TPR 2; 138..173; TPR 3; 181..214; TPR 4; 249..282; TPR 5; 338..371; TPR 6; 376..410; TPR 7; 435..468; TPR 8
Domain (CC)
RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505, PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).
Region
254..260; Interaction with the 5'-triphosphate group of PPP-RNA
Protein Families
IFIT family
Sequence Similarities
Belongs to the IFIT family.
Supporting Publications20
| PMID | Title | Related sentences |
|---|---|---|
| 37702715 | One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles. | No related sentences available |
| 38082559 | Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia. | No related sentences available |
| 38164498 | Enrichment of sweat-derived extracellular vesicles of human and bacterial origin for biomarker identification. | No related sentences available |
| 38612515 | Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature. | No related sentences available |
| 38644352 | The tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment. | No related sentences available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No related sentences available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 40248970 | Chemical Affinity Capture of Plasma Extracellular Vesicles Enables Efficient and Large-Scale Proteomic Identification of Prostate Cancer Biomarkers. | No related sentences available |
| 40640963 | Identification of serum exosome proteins in systemic sclerosis with interstitial lung disease by aptamer proteomics. | No related sentences available |
Page 2 of 2Previous