Protein detail
KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Protein symbol KCC2G | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
CAMKG
Gene Description
Calcium/calmodulin dependent protein kinase II gamma
Chromosome
10
Position
73812501-73874591
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificmonocytesBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004683 calcium/calmodulin-dependent protein kinase activity
- GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0106310 protein serine kinase activity
Biological Process
KEGG
- hsa04012 ErbB signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9609736 assembly and cell surface presentation of nmda receptors
- R-hsa-111932 camk iv mediated phosphorylation of creb
- R-hsa-5576891 cardiac conduction
- R-hsa-111996 ca dependent events
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-442742 creb1 phosphorylation through nmda receptor mediated activation of ras signaling
- R-hsa-442729 creb1 phosphorylation through the activation of camkii camkk camkiv cascasde
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-418594 g alpha i signalling events
- R-hsa-112040 g protein mediated events
- R-hsa-3371571 hsf1 dependent transactivation
- R-hsa-5663205 infectious disease
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-9620244 long term potentiation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-397014 muscle contraction
- R-hsa-9617324 negative regulation of nmda receptor mediated neuronal transmission
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-111885 opioid signalling
- R-hsa-5576892 phase 0 rapid depolarisation
- R-hsa-5673000 raf activation
- R-hsa-442982 ras activation upon ca2 influx through nmda receptor
- R-hsa-9022692 regulation of mecp2 expression and activity
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-372790 signaling by gpcr
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-399719 trafficking of ampa receptors
- R-hsa-8986944 transcriptional regulation by mecp2
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
- R-hsa-438066 unblocking of nmda receptors glutamate binding and activation
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CAMK2G | CAMK2B | Q13554 | T | 287 | phosphorylation | PhosphoSite | |
| CAMK2G | PRKACB | P22694 | S | 333 | phosphorylation | KEA | KEA:17570479 |
| CAMK2G | PRKCA | P17252 | S | 315 | phosphorylation | KEA | KEA:17570479 |
| CAMK2G | PRKCA | P17252 | T | 287 | phosphorylation | KEA | KEA:17570479 |
| CAMK2G | RPS6KA3 | P51812 | T | 287 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
24 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass Spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
558
Mass
62,607
Sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
Alternative Products
Event=Alternative splicing; Named isoforms=11; Name=1; IsoId=Q13555-1; Sequence=Displayed; Name=2; IsoId=Q13555-2; Sequence=VSP_013349; Name=3; IsoId=Q13555-3; Sequence=VSP_013350; Name=4; IsoId=Q13555-4; Sequence=VSP_004778; Name=5; IsoId=Q13555-5; Sequence=VSP_032699, VSP_032700, VSP_004778; Name=6; IsoId=Q13555-6; Sequence=VSP_032699, VSP_035456; Name=7; Synonyms=gamma F; IsoId=Q13555-7; Sequence=VSP_013350, VSP_035456; Name=8; Synonyms=gamma E; IsoId=Q13555-8; Sequence=VSP_013349, VSP_035456; Name=9; Synonyms=gamma D; IsoId=Q13555-9; Sequence=VSP_013349, VSP_036027, VSP_035456; Name=10; IsoId=Q13555-10; Sequence=VSP_013350, VSP_004778; Name=11; IsoId=Q13555-11; Sequence=VSP_059393, VSP_013349, VSP_059394
Alternative Sequence
315; S -> SVGRQSSAPASPAASAAGLAGQ (in isoform 5 and isoform 6); 316; A -> VGRQSSAPASPAASAAGLAGQA (in isoform 11); 331..364; Missing (in isoform 3, isoform 7 and isoform 10); 331..341; Missing (in isoform 2, isoform 8, isoform 9 and isoform 11); 341..363; Missing (in isoform 5); 351..364; Missing (in isoform 9); 396..426; GRVPEGRSSRDRTAPSAGMQPQPSLCSSAMR -> VR (in isoform 11); 396..425; GRVPEGRSSRDRTAPSAGMQPQPSLCSSAM -> V (in isoform 4, isoform 5 and isoform 10); 397..398; RV -> APLRTGNGSSV (in isoform 6, isoform 7, isoform 8 and isoform 9)
3D Structural Models
Turn
34..37; 257..259; 482..485
Helix
9..13; 52..67; 98..103; 110..129; 139..141; 178..180; 183..187; 194..209; 219..227; 237..240; 243..252; 263..266; 270..273; 275..278; 285..301; 425..443; 446..452; 462..464; 471..481
Beta Strand
14..22; 26..33; 38..46; 76..81; 83..91; 142..145; 153..155; 453..460; 468..470; 490..501; 506..518; 524..538; 541..550
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
342..352; Polar residues; 394..408; Basic and acidic residues
Domain (CC)
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Domain (FT)
14..272; Protein kinase
Region
283..292; Autoinhibitory domain; 294..316; Calmodulin-binding; 324..353; Disordered; 376..423; Disordered
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance
Disease Involvement
Intellectual disability
Drugs
Interaction Protein
ENSG00000145349
Interaction Count
1
Interaction Dataset
intact_biogrid