Protein detail

MTR1L

Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]

Entry name MTR1L	UniProt ID Q13585	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 7	Protein classification G-protein coupled receptorsPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]

Protein Class (3)

G-protein coupled receptorsPlasma proteinsPredicted membrane proteins

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

31..51; Helical; Name=1; 65..85; Helical; Name=2; 104..124; Helical; Name=3; 144..164; Helical; Name=4; 189..209; Helical; Name=5; 240..260; Helical; Name=6; 274..294; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000102195

Entrez Gene Symbol

GPR50

Gene Synonym (2)

H9Mel1c

Gene Description

G protein-coupled receptor 50

Chromosome

Position

151176584-151181465

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificEpicardial cellsSingle-Nuclei Brain SpecificLAMP5-LHX6 and ChandelierSecretome LocationSecreted to bloodSecretome FunctionNo annotated function

Function & Pathway6

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Mediation Categories

Other mediation

Relations & Evidence47

Ligand-Receptor Signaling (42)

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

Page 3 of 5Previous Next

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MTR1L	Q13585	ADA17	P78536	Yes	Yes	No	SIGNOR	SIGNOR:32405532

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster501	GPR50 GPR84 LIN28A LIN28B MTNR1A MTNR1B	P48039 P49286 Q13585 Q6ZN17 Q9H9Z2 Q9NQS5	1:1:1:1:1:1	Compleat	Compleat:HC2192	22036573
	GPR50 IRS4 MTNR1A MTNR1B	O14654 P48039 P49286 Q13585	1:1:1:1	CompleatCFinder	Compleat:HC8378
	GPR50 MAS1	P04201 Q13585	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38343172

Sequence, Structure & Domains7

Sequences

Length

617

Mass

67,369

Sequence

MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV

Domain & Motif Annotations

Compositional Bias

341..353; Basic and acidic residues; 485..500; Polar residues

Region

340..438; Disordered; 464..596; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Antibody (2)

HPA049862 HPA054678

Supporting Publications3

PMID	Title	Abstract
34212056	Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis.	CD9-expressing total exosome fractions were from conditioned media of 3D-SFnws and 2D polystyrene plates HDF cultures.
35552651	Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction.	Among trial patients with PD-L1 CPS < 10, unprespecified analysis explored whether extracellular vesicles (EV) could identify further responders: an elevated plasma level of PD-L1-expressing EVs was significantly associated with higher pCR.
35655108	Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review.	The results showed that the concentrations of platelet-derived extracellular vesicles (PEVs) and endothelial cell-derived extracellular vesicles (EEVs) decreased after long-term exercise, especially for CD62E © 2022.