Protein detail

MTR1L

Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]

Entry name MTR1L	UniProt ID Q13585	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 7	Protein classification G-protein coupled receptorsPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]

Protein Class (3)

G-protein coupled receptorsPlasma proteinsPredicted membrane proteins

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

31..51; Helical; Name=1; 65..85; Helical; Name=2; 104..124; Helical; Name=3; 144..164; Helical; Name=4; 189..209; Helical; Name=5; 240..260; Helical; Name=6; 274..294; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000102195

Entrez Gene Symbol

GPR50

Gene Synonym (2)

H9Mel1c

Gene Description

G protein-coupled receptor 50

Chromosome

Position

151176584-151181465

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificEpicardial cellsSingle-Nuclei Brain SpecificLAMP5-LHX6 and ChandelierSecretome LocationSecreted to bloodSecretome FunctionNo annotated function

Function & Pathway6

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Mediation Categories

Other mediation

Relations & Evidence47

Ligand-Receptor Signaling (42)

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
gpcr_orphan	receptor	HGNC	No	Yes	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MTR1L	Q13585	ADA17	P78536	Yes	Yes	No	SIGNOR	SIGNOR:32405532

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster501	GPR50 GPR84 LIN28A LIN28B MTNR1A MTNR1B	P48039 P49286 Q13585 Q6ZN17 Q9H9Z2 Q9NQS5	1:1:1:1:1:1	Compleat	Compleat:HC2192	22036573
	GPR50 IRS4 MTNR1A MTNR1B	O14654 P48039 P49286 Q13585	1:1:1:1	CompleatCFinder	Compleat:HC8378
	GPR50 MAS1	P04201 Q13585	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38343172

Sequence, Structure & Domains7

Sequences

Length

617

Mass

67,369

Sequence

MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV

Domain & Motif Annotations

Compositional Bias

341..353; Basic and acidic residues; 485..500; Polar residues

Region

340..438; Disordered; 464..596; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Antibody (2)

HPA049862 HPA054678

Supporting Publications3

PMID	Title	Abstract
34212056	Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis.	CD9-expressing total exosome fractions were from conditioned media of 3D-SFnws and 2D polystyrene plates HDF cultures.
35552651	Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction.	Among trial patients with PD-L1 CPS < 10, unprespecified analysis explored whether extracellular vesicles (EV) could identify further responders: an elevated plasma level of PD-L1-expressing EVs was significantly associated with higher pCR.
35655108	Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review.	The results showed that the concentrations of platelet-derived extracellular vesicles (PEVs) and endothelial cell-derived extracellular vesicles (EEVs) decreased after long-term exercise, especially for CD62E © 2022.