Protein detail

PTC1

Protein patched homolog 1 (PTC) (PTC1)

Protein symbol PTC1	UniProt ID Q13635	EVMP score 0.25
Frequency 1	Transmembrane count 12	Protein classification Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Protein patched homolog 1 (PTC) (PTC1)

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Human disease related genes:Cancers:Skin cancers
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Transmembrane

101..121; Helical; 437..457; Helical; 473..493; Helical; 502..522; Helical; 548..568; Helical; 578..598; Helical; 749..769; Helical; 1028..1048; Helical; 1056..1076; Helical; 1084..1104; Helical; 1122..1141; Helical; 1155..1175; Helical

Transmembrane Count

Ensembl

ENSG00000185920

Entrez Gene Symbol

PTCH1

Gene Synonym

BCNSNBCCSPTCH

Gene Description

Patched 1

Chromosome

Position

95442980-95517057

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificAstrocytes

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Human disease related genes:Cancers:Skin cancers
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTCH1	CASP3	P42574	D	1,405	cleavage	SIGNOR	SIGNOR:12907805 SIGNOR:23074268

Ligand-Receptor Signaling

46 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
patched	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SHH	Q15465	PTC1	Q13635	Yes	Yes	Yes	iTALKKirouac2010KEGG-MEDICUSICELLNETSIGNORHINTSignaLink3HPMR_talklrHPMRHPRD_LRdbtalklrHPRDCui2007IntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SPIKE_LC:9811851 HINT:31555730 LRdb:9811851 SPIKE_LC:20083481 SignaLink3:14556242 Baccin2019:9811851 connectomeDB2020:9811851 Baccin2019:16867986 BioGRID:16282375 Cellinker:9811851 HINT:29954986 NetPath:8906787 SIGNOR:14556242 SPIKE:20083481 Cellinker:30613383LRdb:169connectomeDB2020:16867986 HINT:29995851 ICELLNET:27647915 HINT:19561609 CellTalkDB:9811851 HPRD:9811851 Cellinker:21339334 IntAct:29954986 SPIKE:9811851 Cellinker:16867986 SignaLink3:23331499 HINT:30139912 HINT:16282375 IntAct:29995851 HPMR:16867986 HINT:31127104 SIGNOR:9811851 SIGNOR:15618519 NetPath:9811851 HINT:31548691 IntAct:30139912
DHH	O43323	PTC1	Q13635	Yes	Yes	Yes	iTALKKirouac2010KEGG-MEDICUSSignaLink3HPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019CancerCellMapWangRamilowski2015HPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SignaLink3:9811851 SignaLink3:19399989 CancerCellMap:8906787 SPIKE_LC:9811851 CellTalkDB:9811851 Baccin2019:9811851 connectomeDB2020:9811851 LRdb:9811851 HPRD:9811851 NetPath:9811851 SPIKE_LC:20083481 Cellinker:9811851 SPIKE:20083481 SPIKE:9811851 SignaLink3:23331499 CancerCellMap:9811851
IHH	Q14623	PTC1	Q13635	Yes	Yes	Yes	iTALKKirouac2010KEGG-MEDICUSICELLNETSIGNORSignaLink3HPMR_talklrHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019CancerCellMapWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SignaLink3:19399989 SPIKE_LC:9811851 connectomeDB2020:11562786 SPIKE_LC:20083481LRdb:98ICELLNET:29274272 connectomeDB2020:9811851 Cellinker:9811851 SPIKE:20083481Baccin2019:115627869811851HPRD:9811851 SPIKE:9811851 SignaLink3:23331499 CellTalkDB:11562786 SIGNOR:9811851 LRdb:11562786 NetPath:9811851 Cellinker:11562786 CancerCellMap:9811851
PTC1	Q13635	SMO	Q99835	Yes	Yes	Yes	WangNetPathSIGNORHPRDCui2007SignaLink3BioGRIDCancerCellMapSPIKE_LCSPIKE	SPIKE_LC:9811851 SPIKE:20207148 BioGRID:9811851 HPRD:9811851 SPIKE_LC:20207148 SPIKE_LC:20076617 NetPath:9811851 SIGNOR:12192414 SPIKE:20076617 NetPath:8906787 SIGNOR:14556242 SPIKE:9811851 SignaLink3:23331499 CancerCellMap:9811851 SignaLink3:14556242
PTC1	Q13635	CCNB1	P14635	Yes	Yes	No	WangSIGNORHPRDHINTBioGRIDCancerCellMapSPIKE_LCSPIKE	CancerCellMap:11331587 HINT:19502428 SIGNOR:11331587 HINT:11331587 SPIKE_LC:11331587 HPRD:9926943 BioGRID:15592520 SPIKE:11331587
SLIK5	O94991	PTC1	Q13635	Yes	No	Yes	SIGNOR	SIGNOR:34326333
CASP3	P42574	PTC1	Q13635	Yes	No	Yes	SIGNOR	SIGNOR:12907805 SIGNOR:23074268
	COMPLEX:P42574	PTC1	Q13635	Yes	No	Yes	SIGNOR	SIGNOR:12907805 SIGNOR:23074268
LRP2	P98164	PTC1	Q13635	Yes	Yes	No	SIGNOR	SIGNOR:26872844
GPC6	Q9Y625	PTC1	Q13635	Yes	Yes	No	SIGNOR	SIGNOR:31756413

Protein Complex Composition

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CDC2-CCNB1-PTCH1 complex	CCNB1 CDK1 PTCH1	P06493 P14635 Q13635	1:1:1	CompleatCORUM	Compleat:HC2850CORUM:5551	11331587
PTCH_GAS1_transmembrane_receptor	GAS1 PTCH1	P54826 Q13635	1:1	CellPhoneDB	CellPhoneDB:PTCH_GAS1_transmembrane_receptor
	DHH PTCH1	O43323 Q13635	0:0	KEGG-MEDICUS
	PTCH1	Q13635	3	PDB	PDB:6rvc
	IHH PTCH1	Q13635 Q14623	0:0	KEGG-MEDICUS
	ABCA2 PON2 PTCH1 ST3GAL6 ST6GALNAC3	Q13635 Q15165 Q8NDV1 Q9BZC7 Q9Y274	0:0:0:0:0	hu.MAP
	PTCH1 SHH	Q13635 Q15465	2:1	KEGG-MEDICUSPDB	PDB:6n7kPDB:6dmyPDB:6n7gPDB:6e1hPDB:6n7hPDB:6oevPDB:6rvd
	PTCH1 UGT3A2	Q13635 Q3SY77	0:0	hu.MAP
	BPNT2 GUCD1 PTCH1	Q13635 Q96NT3 Q9NX62	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 37922300

Sequence, Structure & Domains

Sequences

Length

1,447

Mass

160,545

Sequence

MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=L; Synonyms=1B; IsoId=Q13635-1; Sequence=Displayed; Name=L'; Synonyms=1Ckid; IsoId=Q13635-2; Sequence=VSP_041369; Name=M; Synonyms=1C; IsoId=Q13635-3; Sequence=VSP_041371; Name=S; Synonyms=1A, 1CdeltaE2; IsoId=Q13635-4; Sequence=VSP_041370

Alternative Sequence

1..66; MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQIS -> MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDKETRSD (in isoform L'); 2..152; Missing (in isoform S); 2..67; Missing (in isoform M)

3D Structural Models

Turn

53..55; 256..258; 270..272; 288..293; 309..312; 332..334; 462..464; 500..502; 532..534; 777..780; 957..959; 1103..1106; 1149..1152

Helix

48..51; 58..67; 78..96; 99..113; 114..118; 125..128; 135..146; 172..186; 199..202; 214..223; 231..234; 236..241; 261..269; 276..285; 319..323; 339..342; 350..352; 369..376; 380..382; 389..409; 426..434; 439..457; 467..490; 503..511; 512..514; 515..523; 536..543; 546..553; 556..561; 568..573; 576..590; 592..604; 732..738; 741..744; 747..769; 788..796; 812..814; 816..825; 826..828; 844..864; 878..887; 899..903; 910..912; 919..929; 931..934; 984..1004; 1013..1016; 1017..1019; 1020..1022; 1024..1047; 1051..1074; 1081..1102; 1111..1120; 1124..1137; 1138..1140; 1153..1167; 1170..1177

Beta Strand

74..77; 132..134; 148..150; 155..164; 189..192; 195..198; 205..210; 249..253; 299..301; 336..338; 343..345; 347..349; 354..356; 358..366; 383..385; 413..415; 416..422; 497..499; 526..528; 783..785; 801..809; 829..832; 836..838; 869..871; 873..876; 893..895; 916..918; 972..978; 1007..1012; 1108..1110; 1142..1145; 1146..1148

3D Structure

Electron microscopy (12); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

13..30; Gly residues; 1217..1232; Low complexity; 1349..1358; Polar residues

Domain (FT)

438..598; SSD

Region

1..43; Disordered; 1189..1234; Disordered; 1270..1360; Disordered

Protein Families

Patched family

Sequence Similarities

Belongs to the patched family.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantHoloprosencephalyTumor suppressor

Drugs

VISMODEGIB SONIDEGIB TRETINOIN FORETINIB

Antibody

CAB013717 HPA075072

Interaction Protein

ENSG00000134057ENSG00000173020

Interaction Count

Interaction Dataset

intact_biogrid