Protein detail
AVR2B
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Entry name AVR2B | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Protein Class (6)
Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function (8)
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Transmembrane
138..158; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ActR-IIB
Gene Description
Activin A receptor type 2B
Chromosome
3
Position
38453890-38493142
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization2
Tissue Specificbone marrowCell SpecificCardiomyocytes
Function & Pathway8
Protein Function (8)
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (5)
Molecular Function (11)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004712 protein serine/threonine/tyrosine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016362 activin receptor activity, type II
- GO:0017002 activin receptor activity
- GO:0019209 kinase activator activity
- GO:0019838 growth factor binding
- GO:0046872 metal ion binding
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Biological Process (3)
KEGG (4)
Reactome (5)
Canonical Pathways
M237 Pid vegfr1 2 pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence101
Ligand-Receptor Signaling (67)
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
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Regulatory Interaction Network (16)
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GDF11 | O95390 | AVR2B | Q13705 | Yes | Yes | No | iTALKSIGNORHINTSignaLink3HPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACEFantom5_LRdbCellTalkDBconnectomeDB2020LRdb | HPRD:16845371CellTalkDB:12414726HINT:21054789connectomeDB2020:16845371LRdb:12414726SIGNOR:12414726connectomeDB2020:12414726SIGNOR:16845371LRdb:17SignaLink3:16446785Baccin2019:1241472616845370SignaLink3:16845371SignaLink3:23331499HINT:33961781 |
| NODAL | Q96S42 | AVR2B | Q13705 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015Reactome_LRdbconnectomeDB2020SignaLink3Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACECellCallHPMR_talklr | Baccin2019:11952836CellTalkDB:11952836LRdb:11952836SignaLink3:16446785SignaLink3:23331499HPMR:11952836connectomeDB2020:11952836 |
| GDF5 | P43026 | AVR2B | Q13705 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrconnectomeDB2020HPRDHPRD_talklrSignaLink3Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015 | LRdb:8702914HPRD:8702914Baccin2019:8702914SignaLink3:8702914connectomeDB2020:8702914SignaLink3:16446785SignaLink3:23331499CellTalkDB:8702914 |
| AVR2B | Q13705 | SMAD3 | P84022 | Yes | Yes | No | SIGNOR | SIGNOR:21966641 |
| GDF8 | O14793 | AVR2B | Q13705 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrBaccin2019Ramilowski2015_Baccin2019Lit-BM-17LRdbRamilowski2015 | Lit-BM-17:23829672HPRD:11459935SIGNOR:11459935Baccin2019:11459935CellTalkDB:11459935Lit-BM-17:11459935connectomeDB2020:11459935LRdb:11459935 |
| AVR2B | Q13705 | SMAD2 | Q15796 | Yes | Yes | No | SIGNOR | SIGNOR:21966641 |
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Protein Complex Composition (17)
17 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACVR1BACVR2BINHBA | P08476P36896Q13705 | 1:1:1 | PDB | PDB:7oly | ||
| ACVR2BBMP2BMPR1A | P12643P36894Q13705 | 2:1:1 | PDB | PDB:2h62 | ||
| ACVR2BACVRL1 | P37023Q13705 | 0:0 | ICELLNET | 178786072271017427481709 | ||
| ACVR2BACVRL1GDF2 | P37023Q13705Q9UK05 | 12:12:12 | PDB | PDB:4fao | ||
| ACVR2BDLK1 | P80370Q13705 | 2:2 | hu.MAP2PDB | PDB:9d20 | ||
| ACVR2BANKRD13CDLK1 | P80370Q13705Q8N6S4 | 0:0:0 | hu.MAP2 | |||
| ACVR2B | Q13705 | 2 | PDB | PDB:5nhr |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains12
Sequences
Length
512
Mass
57,724
Sequence
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=ActR-IIB2; IsoId=Q13705-1; Sequence=Displayed; Name=ActR-IIB1; IsoId=Q13705-2; Sequence=Not described
3D Structural Models
Turn
107..110; 256..258; 309..311; 413..417
Helix
36..39; 82..84; 221..223; 224..235; 273..279; 284..302; 324..326; 362..364; 367..370; 378..398; 424..431; 442..446; 448..460; 465..467; 471..482
Beta Strand
27..33; 43..49; 53..55; 57..66; 69..79; 88..91; 94..96; 98..106; 111..114; 191..197; 200..209; 212..219; 247..253; 260..266; 305..308; 312..314; 316..318; 327..329; 335..337; 344..346
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Domain (FT)
190..480; Protein kinase
Region
491..512; Interaction with DYNLT1
Protein Families (3)
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance5
Disease Involvement (3)
Cancer-related genesDisease variantHeterotaxy
Related Diseases
Biomarker
Investigative
Drugs (2)
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 24769233 | Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. | Most interestingly, the involvement of extracellular vesicles in transferring toxic proteins such as α-synuclein and β-amyloid has been postulated as one of the mechanisms involved in the spreading of neurodegeneration to different brain areas. |