Protein detail
PKP1
Plakophilin-1 (Band 6 protein) (B6P)
Entry name PKP1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Plakophilin-1 (Band 6 protein) (B6P)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
B6P
Gene Description
Plakophilin 1
Chromosome
1
Position
201283452-201332993
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Predicted intracellular proteins
Cellular Component
- GO:0001533 cornified envelope
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005882 intermediate filament
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0030057 desmosome
- GO:0048471 perinuclear region of cytoplasm
- GO:0097165 nuclear stress granule
- GO:0101003 ficolin-1-rich granule membrane
Molecular Function
Biological Process
Reactome
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-351906 apoptotic cleavage of cell adhesion proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-6809371 formation of the cornified envelope
- R-hsa-168249 innate immune system
- R-hsa-6805567 keratinization
- R-hsa-6798695 neutrophil degranulation
- R-hsa-5357801 programmed cell death
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
24 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKP1 | AKT2 | P31751 | S | 63 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | T | 179 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | S | 191 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | T | 180 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | S | 127 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | S | 118 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | S | 65 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | T | 171 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | T | 82 | phosphorylation | PhosphoSite | |
| PKP1 | AKT2 | P31751 | T | 61 | phosphorylation | PhosphoSite |
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Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| adhesion | adhesion | MCAM | Yes | Yes | No | No | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | No | No |
| focal_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AKT2 | P31751 | PKP1 | Q13835 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:23444369PhosphoSite:23444369 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
747
Mass
82,861
Sequence
MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=1b; IsoId=Q13835-1; Sequence=Displayed; Name=1; Synonyms=1a; IsoId=Q13835-2; Sequence=VSP_006735
Alternative Sequence
412..432; Missing (in isoform 1)
3D Structural Models
Turn
483..485
Helix
247..255; 260..272; 279..285; 288..295; 301..315; 319..327; 331..338; 344..358; 364..378; 381..384; 400..411; 438..444; 450..464; 472..482; 486..489; 493..499; 539..544; 546..558; 562..575; 582..591; 597..603; 609..623; 626..628; 629..635; 637..642; 654..669; 674..679; 682..686; 689..693; 698..709
Beta Strand
360..362; 579..581; 712..714
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Repeat
243..274; ARM 1; 275..316; ARM 2; 317..359; ARM 3; 360..415; ARM 4; 416..463; ARM 5; 525..556; ARM 6; 557..603; ARM 7; 604..649; ARM 8; 650..713; ARM 9
Region
1..286; Required for interaction with EIF4A1; 1..234; Required for binding to single stranded DNA; 48..68; Disordered; 54..69; Phosphorylation in this region is required for cytoplasmic localization and protein stabilization; 116..191; Phosphorylation in this region is required for cytoplasmic localization and protein stabilization; 160..269; Required for WNT-mediated nuclear localization
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.