Protein detail

PKP1

Plakophilin-1 (Band 6 protein) (B6P)

Entry name PKP1	UniProt ID Q13835	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Plakophilin-1 (Band 6 protein) (B6P)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of skin
Predicted intracellular proteins

Ensembl

ENSG00000081277

Entrez Gene Symbol

PKP1

Gene Synonym

B6P

Gene Description

Plakophilin 1

Chromosome

Position

201283452-201332993

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of skin
Predicted intracellular proteins

Cellular Component (11)

Page 1 of 2

Molecular Function (7)

Biological Process (3)

KEGG (2)

Reactome (9)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence41

Enzyme-Mediated Modification (24)

24 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PKP1	AKT2	P31751	S	63	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	T	179	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	S	191	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	T	180	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	S	127	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	S	118	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	S	65	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	T	171	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	T	82	phosphorylation	PhosphoSite
PKP1	AKT2	P31751	T	61	phosphorylation	PhosphoSite

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Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plakophilin_adhesion_regulator	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AKT2	P31751	PKP1	Q13835	Yes	Yes	No	PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:23444369 PhosphoSite:23444369

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PKP1-ZO-1 complex	PKP1 TJP1	Q07157 Q13835	0:0	CORUM	CORUM:6351	27015268

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	2	32384937 32301581

Sequence, Structure & Domains13

Sequences

Length

747

Mass

82,861

Sequence

MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=1b; IsoId=Q13835-1; Sequence=Displayed; Name=1; Synonyms=1a; IsoId=Q13835-2; Sequence=VSP_006735

Alternative Sequence

412..432; Missing (in isoform 1)

3D Structural Models

Turn

483..485

Helix

247..255; 260..272; 279..285; 288..295; 301..315; 319..327; 331..338; 344..358; 364..378; 381..384; 400..411; 438..444; 450..464; 472..482; 486..489; 493..499; 539..544; 546..558; 562..575; 582..591; 597..603; 609..623; 626..628; 629..635; 637..642; 654..669; 674..679; 682..686; 689..693; 698..709

Beta Strand

360..362; 579..581; 712..714

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Repeat

243..274; ARM 1; 275..316; ARM 2; 317..359; ARM 3; 360..415; ARM 4; 416..463; ARM 5; 525..556; ARM 6; 557..603; ARM 7; 604..649; ARM 8; 650..713; ARM 9

Region

1..286; Required for interaction with EIF4A1; 1..234; Required for binding to single stranded DNA; 48..68; Disordered; 54..69; Phosphorylation in this region is required for cytoplasmic localization and protein stabilization; 116..191; Phosphorylation in this region is required for cytoplasmic localization and protein stabilization; 160..269; Required for WNT-mediated nuclear localization

Protein Families

Beta-catenin family

Sequence Similarities

Belongs to the beta-catenin family.

Clinical Relevance5

Disease Involvement

Ectodermal dysplasia

Antibody (2)

HPA027221 CAB033130

Interaction Protein

ENSG00000006704

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.