Protein detail
CEAM7
Cell adhesion molecule CEACAM7 (Carcinoembryonic antigen CGM2) (Carcinoembryonic antigen-related cell adhesion molecule 7) (CEA cell adhesion molecule 7)
Entry name CEAM7 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Cell adhesion molecule CEACAM7 (Carcinoembryonic antigen CGM2) (Carcinoembryonic antigen-related cell adhesion molecule 7) (CEA cell adhesion molecule 7)
Protein Class
Predicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CEACGM2
Gene Description
CEA cell adhesion molecule 7
Chromosome
19
Position
41673303-41706976
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway5
Cellular Component (6)
Molecular Function
Biological Process (3)
Reactome (2)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence23
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ig_like | adhesion | Almen2009 | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 36337342 |
Sequence, Structure & Domains12
Sequences
Length
265
Mass
29,345
Sequence
MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGIYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVENKDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEIQNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2a; IsoId=Q14002-1; Sequence=Displayed; Name=2b; IsoId=Q14002-2; Sequence=VSP_002488
Alternative Sequence
143..235; Missing (in isoform 2b)
3D Structural Models
Turn
84..87
Helix
75..77; 115..117
Beta Strand
37..46; 51..56; 62..71; 78..83; 100..102; 108..110; 119..127; 133..142
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
36..142; Ig-like V-type; 146..233; Ig-like C2-type
Protein Families (2)
- Immunoglobulin superfamily
- CEA family
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32396726 | Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification. | No abstract available |