Protein detail

CEAM7

Cell adhesion molecule CEACAM7 (Carcinoembryonic antigen CGM2) (Carcinoembryonic antigen-related cell adhesion molecule 7) (CEA cell adhesion molecule 7)

Entry name CEAM7	UniProt ID Q14002	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Cell adhesion molecule CEACAM7 (Carcinoembryonic antigen CGM2) (Carcinoembryonic antigen-related cell adhesion molecule 7) (CEA cell adhesion molecule 7)

Protein Class

Predicted membrane proteins

Ensembl

ENSG00000007306

Entrez Gene Symbol

CEACAM7

Gene Synonym (2)

CEACGM2

Gene Description

CEA cell adhesion molecule 7

Chromosome

Position

41673303-41706976

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway5

Cellular Component (6)

Molecular Function

GO:1990782 protein tyrosine kinase binding

Biological Process (3)

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CEACAM7	Q14002	4	PDB	PDB:4y89

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	36337342

Sequence, Structure & Domains12

Sequences

Length

265

Mass

29,345

Sequence

MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGIYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVENKDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEIQNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=2a; IsoId=Q14002-1; Sequence=Displayed; Name=2b; IsoId=Q14002-2; Sequence=VSP_002488

Alternative Sequence

143..235; Missing (in isoform 2b)

3D Structural Models

Turn

84..87

Helix

75..77; 115..117

Beta Strand

37..46; 51..56; 62..71; 78..83; 100..102; 108..110; 119..127; 133..142

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

36..142; Ig-like V-type; 146..233; Ig-like C2-type

Protein Families (2)

Immunoglobulin superfamily
CEA family

Sequence Similarities

Belongs to the immunoglobulin superfamily. CEA family.

Clinical Relevance2

Drugs

RECOMBINANT INTERFERON

Antibody (2)

HPA069621 HPA073910

Supporting Publications1

PMID	Title	Abstract
32396726	Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification.	No abstract available