Protein detail

OPCM

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Protein symbol OPCM	UniProt ID Q14982	EVMP score 0.25
Frequency 1	Transmembrane count	Protein classification

Basic Information

Protein Names

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Protein Function

Human disease related genes:Cancers:Cancers of the breast and female genital organs
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000183715

Entrez Gene Symbol

OPCML

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificintestineCell SpecificEnterocytesBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the breast and female genital organs
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	No	Yes
extracellular	extracellular	OmniPath	No	No	No	No	Yes
intracellular	intracellular	LOCATE	No	No	No	No	Yes
intracellular	intracellular	OmniPath	No	No	No	No	Yes
iglon	cell_adhesion	HGNC	Yes	Yes	No	No	Yes
adhesion	adhesion	HGNC	Yes	Yes	No	No	Yes
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	Yes
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	No	Yes
icam	cell_adhesion	Zhong2015	Yes	Yes	No	No	Yes
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	No	Yes

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	OPCML	Q14982	2	PDB	PDB:5uv6

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	4	38731868 26775013 30071318 36362114

Sequence, Structure & Domains

Sequences

Length

345

Mass

38,008

Sequence

MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q14982-1; Sequence=Displayed; Name=2; IsoId=Q14982-2; Sequence=VSP_043440; Name=3; IsoId=Q14982-3; Sequence=VSP_047730; Name=4; IsoId=Q14982-4; Sequence=VSP_054155

Alternative Sequence

1..41; Missing (in isoform 3); 1..27; MGVCGYLFLPWKCLVVVSLRLLFLVPT -> MYHPAYWVVFSATTALLFIP (in isoform 2); 312; Y -> YEISPSSAVA (in isoform 4)

3D Structural Models

Turn

288..290

Helix

107..109; 194..196

Beta Strand

44..48; 53..58; 63..70; 73..77; 88..94; 97..102; 111..121; 127..141; 145..148; 153..163; 166..171; 180..191; 198..205; 207..209; 212..228; 240..250; 253..258; 270..274; 276..285; 292..300; 303..312

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

39..126; Ig-like C2-type 1; 136..219; Ig-like C2-type 2; 223..310; Ig-like C2-type 3

Protein Families

Immunoglobulin superfamily
IgLON family

Sequence Similarities

Belongs to the immunoglobulin superfamily. IgLON family.

Clinical Relevance

Drugs

METHYLPHENIDATE HYDROCHLORIDE