Protein detail

OPCM

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Entry name
OPCM
UniProt ID
Q14982
EVMP confidence score
0.25
Supporting publications (n)
1
Transmembrane count
Protein classification
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information6
Protein Names
Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)
Protein Function (3)
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Disease related genes
  • Predicted intracellular proteins
Ensembl
ENSG00000183715
Entrez Gene Symbol
OPCML
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue SpecificintestineCell SpecificEnterocytesBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function (3)
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (3)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Reactome (2)
Mediation Categories
Metabolism mediation
Relations & Evidence25

Ligand-Receptor Signaling (23)

23 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularHPMRNoNoNoNoYes
extracellularextracellularOmniPathNoNoNoNoYes
intracellularintracellularLOCATENoNoNoNoYes
intracellularintracellularOmniPathNoNoNoNoYes
igloncell_adhesionHGNCYesYesNoNoYes
adhesionadhesionHGNCYesYesNoNoYes
cell_adhesioncell_adhesionCellinkerYesYesNoNoYes
cell_adhesioncell_adhesionZhong2015YesYesNoNoYes
icamcell_adhesionZhong2015YesYesNoNoYes
cell_adhesioncell_adhesionHGNCYesYesNoNoYes
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
OPCMLQ149822PDBPDB:5uv6

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryWestern blottingELISA438731868267750133007131836362114
Sequence, Structure & Domains12

Sequences

Length
345
Mass
38,008
Sequence
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q14982-1; Sequence=Displayed; Name=2; IsoId=Q14982-2; Sequence=VSP_043440; Name=3; IsoId=Q14982-3; Sequence=VSP_047730; Name=4; IsoId=Q14982-4; Sequence=VSP_054155
Alternative Sequence
1..41; Missing (in isoform 3); 1..27; MGVCGYLFLPWKCLVVVSLRLLFLVPT -> MYHPAYWVVFSATTALLFIP (in isoform 2); 312; Y -> YEISPSSAVA (in isoform 4)

3D Structural Models

Turn
288..290
Helix
107..109; 194..196
Beta Strand
44..48; 53..58; 63..70; 73..77; 88..94; 97..102; 111..121; 127..141; 145..148; 153..163; 166..171; 180..191; 198..205; 207..209; 212..228; 240..250; 253..258; 270..274; 276..285; 292..300; 303..312
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)
39..126; Ig-like C2-type 1; 136..219; Ig-like C2-type 2; 223..310; Ig-like C2-type 3
Protein Families (2)
  • Immunoglobulin superfamily
  • IgLON family
Sequence Similarities
Belongs to the immunoglobulin superfamily. IgLON family.
Clinical Relevance1
Drugs
METHYLPHENIDATE HYDROCHLORIDE
Supporting Publications1
PMIDTitleAbstract
32331267Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules.No abstract available