Protein detail

OPCM

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Protein symbol OPCM	UniProt ID Q14982	EVMP score 0.25
Frequency 1	Transmembrane count	Protein classification

Basic Information

Protein Names

Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)

Protein Function

Human disease related genes:Cancers:Cancers of the breast and female genital organs
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000183715

Entrez Gene Symbol

OPCML

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificintestineCell SpecificEnterocytesBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the breast and female genital organs
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
adhesion	adhesion	OmniPath	Yes	Yes	No	No	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	Yes
transmembrane	transmembrane	LOCATE	No	No	No	No	Yes
transmembrane	transmembrane	OmniPath	No	No	No	No	Yes
peripheral	peripheral	UniProt_location	No	No	No	No	Yes
peripheral	peripheral	OmniPath	No	No	No	No	Yes
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	Yes
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	Yes
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA	No	No	No	No	Yes

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	OPCML	Q14982	2	PDB	PDB:5uv6

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	4	38731868 26775013 30071318 36362114

Sequence, Structure & Domains

Sequences

Length

345

Mass

38,008

Sequence

MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q14982-1; Sequence=Displayed; Name=2; IsoId=Q14982-2; Sequence=VSP_043440; Name=3; IsoId=Q14982-3; Sequence=VSP_047730; Name=4; IsoId=Q14982-4; Sequence=VSP_054155

Alternative Sequence

1..41; Missing (in isoform 3); 1..27; MGVCGYLFLPWKCLVVVSLRLLFLVPT -> MYHPAYWVVFSATTALLFIP (in isoform 2); 312; Y -> YEISPSSAVA (in isoform 4)

3D Structural Models

Turn

288..290

Helix

107..109; 194..196

Beta Strand

44..48; 53..58; 63..70; 73..77; 88..94; 97..102; 111..121; 127..141; 145..148; 153..163; 166..171; 180..191; 198..205; 207..209; 212..228; 240..250; 253..258; 270..274; 276..285; 292..300; 303..312

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

39..126; Ig-like C2-type 1; 136..219; Ig-like C2-type 2; 223..310; Ig-like C2-type 3

Protein Families

Immunoglobulin superfamily
IgLON family

Sequence Similarities

Belongs to the immunoglobulin superfamily. IgLON family.

Clinical Relevance

Drugs

METHYLPHENIDATE HYDROCHLORIDE