Protein detail

HECAM

Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)

Protein symbol HECAM	UniProt ID Q14CZ8	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

241..261; Helical

Transmembrane Count

Ensembl

ENSG00000165478

Entrez Gene Symbol

HEPACAM

Gene Synonym

FLJ25530GLIALCAM

Gene Description

Hepatic and glial cell adhesion molecule

Chromosome

Position

124919205-124936412

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Biological Process

Canonical Pathways

M31 Pid beta catenin deg pathway
M200 Pid era genomic pathway
M223 Pid beta catenin nuc pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
matrix_adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HEPACAM	Q14CZ8	2	PDB	PDB:7uqc
	C1orf87 HEPACAM	Q14CZ8 Q8N0U7	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	5	38731868 23585444 26801919 27723984 40091455

Sequence, Structure & Domains

Sequences

Length

416

Mass

46,026

Sequence

MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CZ8-1; Sequence=Displayed; Name=2; IsoId=Q14CZ8-2; Sequence=VSP_052497, VSP_052498

Alternative Sequence

293..367; ADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPAR -> GELPATQSPIPSTIRSVGCWEKAELGDKENSSAGTLPSDLGASKGKEPEPASLASSHSLPRRHAMPSTLSVSVHE (in isoform 2); 368..416; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

285..306; Basic and acidic residues; 383..398; Low complexity

Domain (CC)

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.

Domain (FT)

34..142; Ig-like V-type; 148..234; Ig-like C2-type

Region

273..416; Disordered

Clinical Relevance

Disease Involvement

Disease variant

Antibody

HPA017613 CAB025486