Protein detail

HECAM

Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)

Entry name HECAM	UniProt ID Q14CZ8	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

241..261; Helical

Transmembrane Count

Ensembl

ENSG00000165478

Entrez Gene Symbol

HEPACAM

Gene Synonym (2)

FLJ25530GLIALCAM

Gene Description

Hepatic and glial cell adhesion molecule

Chromosome

Position

124919205-124936412

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (5)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (4)

Biological Process (3)

Canonical Pathways (3)

M31 Pid beta catenin deg pathway
M200 Pid era genomic pathway
M223 Pid beta catenin nuc pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HEPACAM	Q14CZ8	2	PDB	PDB:7uqc
	C1orf87 HEPACAM	Q14CZ8 Q8N0U7	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	5	38731868 23585444 26801919 27723984 40091455

Sequence, Structure & Domains10

Sequences

Length

416

Mass

46,026

Sequence

MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CZ8-1; Sequence=Displayed; Name=2; IsoId=Q14CZ8-2; Sequence=VSP_052497, VSP_052498

Alternative Sequence

293..367; ADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPAR -> GELPATQSPIPSTIRSVGCWEKAELGDKENSSAGTLPSDLGASKGKEPEPASLASSHSLPRRHAMPSTLSVSVHE (in isoform 2); 368..416; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

285..306; Basic and acidic residues; 383..398; Low complexity

Domain (CC)

The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.

Domain (FT)

34..142; Ig-like V-type; 148..234; Ig-like C2-type

Region

273..416; Disordered

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (2)

HPA017613 CAB025486

Supporting Publications1

PMID	Title	Abstract
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available