Protein detail

HECAM

Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)

Entry name
HECAM
UniProt ID
Q14CZ8
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
1
Protein classification
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
Transmembrane
241..261; Helical
Transmembrane Count
1
Ensembl
ENSG00000165478
Entrez Gene Symbol
HEPACAM
Gene Synonym (2)
FLJ25530GLIALCAM
Gene Description
Hepatic and glial cell adhesion molecule
Chromosome
11
Position
124919205-124936412
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (5)
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
Cellular Component (4)
Biological Process (3)
Canonical Pathways (3)
  • M31 Pid beta catenin deg pathway
  • M200 Pid era genomic pathway
  • M223 Pid beta catenin nuc pathway
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membrane_transmembraneplasma_membrane_transmembraneCSPAYes
plasma_membrane_transmembraneplasma_membrane_transmembraneOmniPathYes
cell_surfacecell_surfaceSurfaceomeYes
cell_surfacecell_surfaceOmniPathYes
transmembranetransmembrane_predictedPhobiusYes
transmembrane_phobiustransmembrane_predictedAlmen2009Yes
transmembrane_sosuitransmembrane_predictedAlmen2009Yes
transmembrane_tmhmmtransmembrane_predictedAlmen2009Yes
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HEPACAMQ14CZ82PDBPDB:7uqc
C1orf87HEPACAMQ14CZ8Q8N0U70:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingFlow cytometry53873186823585444268019192772398440091455
Sequence, Structure & Domains

Sequences

Length
416
Mass
46,026
Sequence
MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CZ8-1; Sequence=Displayed; Name=2; IsoId=Q14CZ8-2; Sequence=VSP_052497, VSP_052498
Alternative Sequence
293..367; ADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPAR -> GELPATQSPIPSTIRSVGCWEKAELGDKENSSAGTLPSDLGASKGKEPEPASLASSHSLPRRHAMPSTLSVSVHE (in isoform 2); 368..416; Missing (in isoform 2)

3D Structural Models

3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
285..306; Basic and acidic residues; 383..398; Low complexity
Domain (CC)
The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.
Domain (FT)
34..142; Ig-like V-type; 148..234; Ig-like C2-type
Region
273..416; Disordered
Clinical Relevance
Disease Involvement
Disease variant
Antibody (2)
HPA017613CAB025486
Supporting Publications1
PMIDTitleRelated sentences
32230970Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.No related sentences available