Protein detail
S39AE
Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Entry name S39AE | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
158..178; Helical; 187..207; Helical; 225..245; Helical; 398..418; Helical; 425..445; Helical; 461..481; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0062NET34ZIP14
Gene Description
Solute carrier family 39 member 14
Chromosome
8
Position
22367278-22434129
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatidsBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component
Molecular Function
- GO:0005381 iron ion transmembrane transporter activity
- GO:0005384 manganese ion transmembrane transporter activity
- GO:0005385 zinc ion transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015086 cadmium ion transmembrane transporter activity
- GO:0015093 ferrous iron transmembrane transporter activity
- GO:0015296 monoatomic anion:monoatomic cation symporter activity
- GO:0140410 monoatomic cation:bicarbonate symporter activity
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37338870 |
Sequence, Structure & Domains
Sequences
Length
492
Mass
54,212
Sequence
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAGSHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ZIP14B; IsoId=Q15043-1; Sequence=Displayed; Name=3; IsoId=Q15043-2; Sequence=VSP_029728; Name=2; Synonyms=ZIP14A; IsoId=Q15043-3; Sequence=VSP_040139
Alternative Sequence
156..199; YGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLY -> FGFLSVSLINLASLLGVLVLPCTEKAFFSRVLTYFIALSIGTLL (in isoform 2); 445..492; FPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG -> MEFCSVAQAGVQWCHLSSLQPLPLGLKRLSCLSLPSN (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Motif
251..258; HHHGHXHX-motif; 376..381; XEXPHE-motif
Protein Families
ZIP transporter (TC 2.A.5) family
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Clinical Relevance
Disease Involvement
Disease variantDystoniaNeurodegenerationParkinsonism
Drugs