Protein detail
S39AE
Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Entry name S39AE | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Protein Class (7)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
158..178; Helical; 187..207; Helical; 225..245; Helical; 398..418; Helical; 425..445; Helical; 461..481; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
KIAA0062NET34ZIP14
Gene Description
Solute carrier family 39 member 14
Chromosome
8
Position
22367278-22434129
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificEarly spermatidsBlood Cell Specificneutrophil
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component (7)
Molecular Function (8)
- GO:0005381 iron ion transmembrane transporter activity
- GO:0005384 manganese ion transmembrane transporter activity
- GO:0005385 zinc ion transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015086 cadmium ion transmembrane transporter activity
- GO:0015093 ferrous iron transmembrane transporter activity
- GO:0015296 monoatomic anion:monoatomic cation symporter activity
- GO:0140410 monoatomic cation:bicarbonate symporter activity
Biological Process (3)
Reactome (5)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37338870 |
Sequence, Structure & Domains8
Sequences
Length
492
Mass
54,212
Sequence
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAGSHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ZIP14B; IsoId=Q15043-1; Sequence=Displayed; Name=3; IsoId=Q15043-2; Sequence=VSP_029728; Name=2; Synonyms=ZIP14A; IsoId=Q15043-3; Sequence=VSP_040139
Alternative Sequence
156..199; YGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLY -> FGFLSVSLINLASLLGVLVLPCTEKAFFSRVLTYFIALSIGTLL (in isoform 2); 445..492; FPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG -> MEFCSVAQAGVQWCHLSSLQPLPLGLKRLSCLSLPSN (in isoform 3)
Domain & Motif Annotations
Motif
251..258; HHHGHXHX-motif; 376..381; XEXPHE-motif
Protein Families
ZIP transporter (TC 2.A.5) family
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Clinical Relevance3
Disease Involvement (4)
Disease variantDystoniaNeurodegenerationParkinsonism
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37886648 | Pathological mechanisms of type 1 diabetes in children: investigation of the exosomal protein expression profile. | No abstract available |