Protein detail
PDCD1
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Protein symbol PDCD1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Protein Class
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Transmembrane
171..191; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD279hSLE1PD-1PD1SLEB2
Gene Description
Programmed cell death 1
Chromosome
2
Position
241849884-241858894
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificColonocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-389948 co inhibition by pd 1
- R-hsa-5663205 infectious disease
- R-hsa-9931295 pd l1 cd274 glycosylation and translocation to plasma membrane
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909615 regulation of pd l1 cd274 post translational modification
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-9679506 sars cov infections
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| checkpoint | receptor | ICELLNET | No | Yes | No | Yes | No |
| checkpoint_b7 | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
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Regulatory Interaction Network
6 records.
Protein Complex Composition
23 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39277144 |
Sequence, Structure & Domains
Sequences
Length
288
Mass
31,647
Sequence
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
3D Structural Models
Helix
84..86; 115..117
Beta Strand
27..29; 36..38; 40..45; 46..48; 50..55; 59..61; 63..70; 72..74; 77..83; 87..90; 94..99; 103..112; 119..127; 129..131; 133..136; 140..145
3D Structure
NMR spectroscopy (2); X-ray crystallography (34)
Domain & Motif Annotations
Compositional Bias
278..288; Basic and acidic residues
Motif
221..226; ITIM motif; 247..251; ITSM motif
Domain (FT)
35..145; Ig-like V-type
Region
25..34; Nivolumab binding; 70..77; Interaction with CD274/PDCD1L1; 74..99; Pembrolizumab binding; 254..288; Disordered
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
DOSTARLIMABTEBOTELIMABCAMRELIZUMABPIDILIZUMABCADONILIMABAMP-224VUDALIMABTISLELIZUMABPUCOTENLIMABGEPTANOLIMABSASANLIMABCT-011PEMBROLIZUMABNIVOLUMABSPARTALIZUMABTORIPALIMABPENPULIMABCS-1003SINTILIMABCC-90006CEMIPLIMAB-RWLCBALSTILIMABMEDI0680CETRELIMABBINTRAFUSP ALFAPIMIVALIMABDURVALUMABANTI-PD-1 MONOCLONAL ANTIBODY SYM021RETIFANLIMABSERPLULIMABZIMBERELIMABRO-7121661APL-501AUNP-12EZABENLIMABBUDIGALIMABFINOTONLIMABLIPUSTOBART
Interaction Protein
ENSG00000120217
Interaction Count
1
Interaction Dataset
intact_biogrid