Protein detail

PDCD1

Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

Protein symbol PDCD1	UniProt ID Q15116	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

Protein Class

CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Transmembrane

171..191; Helical

Transmembrane Count

Ensembl

ENSG00000188389

Entrez Gene Symbol

PDCD1

Gene Synonym

CD279hSLE1PD-1PD1SLEB2

Gene Description

Programmed cell death 1

Chromosome

Position

241849884-241858894

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificColonocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
checkpoint	receptor	ICELLNET	No	Yes	No	Yes	No
checkpoint_b7	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No

Page 1 of 5Next

Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PDCD1	Q15116	PTN6	P29350	Yes	Yes	No	KEGG-MEDICUSWangSignaLink3TCRcuration_SignaLink3	SignaLink3:11160222 SignaLink3:15240681 SignaLink3:15358536 SignaLink3:23109003
PTN11	Q06124	PDCD1	Q15116	Yes	No	Yes	HINTSIGNORIntAct	IntAct:15240681 SIGNOR:32437509 HINT:32064351 HINT:28046066 HINT:15240681 IntAct:28046066
PDCD1	Q15116	PTN11	Q06124	Yes	Yes	No	KEGG-MEDICUSHINTSignaLink3IntActTCRcuration_SignaLink3	IntAct:15240681 SignaLink3:11160222 SignaLink3:15240681 SignaLink3:23109003 SignaLink3:15358536 HINT:32064351 HINT:28046066 HINT:15240681 IntAct:28046066
CDK1	P06493	PDCD1	Q15116	Yes	No	Yes	SIGNOR	SIGNOR:36104103
PD1L1	Q9NZQ7	PDCD1	Q15116	Yes	Yes	No	iTALKKEGG-MEDICUSICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17CellChatDBscConnectHPRDWojtowicz2020IntActWangCellPhoneDBBioGRIDCellinkerGuide2PharmaCellTalkDBconnectomeDB2020LRdb	InnateDB:18841514 InnateDB:11015443 IntAct:20587542 HINT:26602187 CellChatDB:23954143 BioGRID:36657039 HINT:36657039 IntAct:23417675 IntAct:21982860 HINT:31802034 LRdb:12889478 HPRD:12719480 Cellinker:26681673 HINT:23417675 Lit-BM-17:21982860 Cellinker:31757674 HINT:11015443 SIGNOR:11015443 HINT:12893276 Cellinker:23954143 HINT:21982860 InnateDB:12893276 HINT:27618663 DIP:26602187 HPRD:12893276 connectomeDB2020:23954143 HINT:20587542 ICELLNET:23954143 InnateDB:21422170
	COMPLEX:P63208_Q13616_Q969H0	PDCD1	Q15116	Yes	No	Yes	SIGNOR	SIGNOR:36104103

Protein Complex Composition

23 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DDX51 NOL8 PDCD11 URB1 URB2 WDR89	O60287 Q14146 Q14690 Q76FK4 Q8N8A6 Q96FK6	0:0:0:0:0:0	hu.MAP2
EMG1 MPG NPM1 NPM3 PDCD11 PELP1 RPP25L SCAF1 SKIC3 TEX10 USP36	O75607 P06748 P29372 Q14690 Q6PGP7 Q8IZL8 Q8N5L8 Q92979 Q9H7N4 Q9NXF1 Q9P275	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
ATG16L1 CCT2 CCT3 CCT4 CCT6A CCT7 IGBP1 PDCD11 PPP2CB PPP2R2A PPP2R2C PPP2R2D PPP4C TCP1 UBC	P0CG48 P17987 P40227 P49368 P50991 P60510 P62714 P63151 P78318 P78371 Q14690 Q66LE6 Q676U5 Q99832 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7649
PDCD10 PXN	P49023 Q9BUL8	1:4	PDB	PDB:3rqePDB:3rqgPDB:3rqf
CEBPZ DDX54 NOC2L PDCD11	Q03701 Q14690 Q8TDD1 Q9Y3T9	0:0:0:0	hu.MAP2
CEBPZ MAK16 NOC2L PDCD11	Q03701 Q14690 Q9BXY0 Q9Y3T9	0:0:0:0	hu.MAP2
PDCD1 PTPN11	Q06124 Q15116	2:2	PDB	PDB:6royPDB:6rozPDB:6r5g
PDCD1	Q15116	4	PDB	PDB:8u32PDB:9hk1PDB:6jjpPDB:6j15PDB:5ggrPDB:7bxaPDB:8gy5PDB:7cu5PDB:5jxePDB:5b8cPDB:5ggsPDB:7wvmPDB:7cgwPDB:8as0
PDCD1 RAB5IF SLC25A28	Q15116 Q96A46 Q9BUV8	0:0:0	hu.MAP2
PDCD1 RAB5IF	Q15116 Q9BUV8	0:0	hu.MAP2

Page 2 of 3Previous Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39277144

Sequence, Structure & Domains

Sequences

Length

288

Mass

31,647

Sequence

MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL

3D Structural Models

Helix

84..86; 115..117

Beta Strand

27..29; 36..38; 40..45; 46..48; 50..55; 59..61; 63..70; 72..74; 77..83; 87..90; 94..99; 103..112; 119..127; 129..131; 133..136; 140..145

3D Structure

NMR spectroscopy (2); X-ray crystallography (34)

Domain & Motif Annotations

Compositional Bias

278..288; Basic and acidic residues

Motif

221..226; ITIM motif; 247..251; ITSM motif

Domain (FT)

35..145; Ig-like V-type

Region

25..34; Nivolumab binding; 70..77; Interaction with CD274/PDCD1L1; 74..99; Pembrolizumab binding; 254..288; Disordered

Clinical Relevance

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Antibody

HPA035981 CAB038418 CAB076386

Interaction Protein

ENSG00000120217

Interaction Count

Interaction Dataset

intact_biogrid