Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein symbol KPCD1 | UniProt ID | EVMP score 0.72 |
Frequency 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Frequency
16
EVMP Score
0.72
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
- GO:0141038 phosphatidylinositol 3-kinase activator activity
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | PRKCD | Q05655 | S | 738 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018SIGNOR:15024053ProtMapper:15024053phosphoELM:15024053KEA:11948398KEA:15383279ProtMapper:23109817KEA:11741879 |
| PRKD1 | PRKCD | Q05655 | S | 412 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PRKD1 | PRKCD | Q05655 | S | 205 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCD | Q05655 | S | 420 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCD | Q05655 | S | 910 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCD | Q05655 | S | 249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PRKD1 | ABL1 | P00519 | Y | 502 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper | KEA:12637538ProtMapper:12637538phosphoELM:12637538SIGNOR:12637538 |
| PRKD1 | ABL1 | P00519 | Y | 463 | phosphorylation | BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:12637538ProtMapper:15024053ProtMapper:15212693SIGNOR:12637538KEA:12637538ProtMapper:23329794phosphoELM:12505989phosphoELM:12637538KEA:12505989ProtMapper:12505989ProtMapper:28174535 |
| PRKD1 | ABL1 | P00519 | Y | 432 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper | KEA:12637538ProtMapper:12637538phosphoELM:12637538SIGNOR:12637538 |
| PRKD1 | ABL1 | P00519 | S | 742 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:15024053 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD1 | Q15139 | SRC8 | Q14247 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:21680539ProtMapper:19038333SIGNOR:20363754ProtMapper:29152154ProtMapper:31727638ProtMapper:26490115ProtMapper:20363754SIGNOR:19038333 |
| KPCD1 | Q15139 | FA83G | A6ND36 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:32570757SIGNOR:32570757 |
| KPCD1 | Q15139 | RTKN | Q9BST9 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSite | ProtMapper:24025634PhosphoSite:22228765SIGNOR:22228765 |
| KPCD1 | Q15139 | P85A | P27986 | Yes | Yes | No | iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:23129748 |
| KPCD1 | Q15139 | ATP7B | P35670 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21189263PhosphoSite:19520855SIGNOR:21189263 |
| KPCD1 | Q15139 | PK3C3 | Q8NEB9 | Yes | Yes | No | RLIMS-P_ProtMapperSIGNORProtMapper | SIGNOR:22095288ProtMapper:22095288 |
| KPCA | P17252 | KPCD1 | Q15139 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksKinexus_KEAWangPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperPhosphoSite | KEA:15024053KEA:10867018ProtMapper:15212693KEA:11948398KEA:15383279phosphoELM:15383279SIGNOR:10197446PhosphoSite:18337243KEA:11741879phosphoELM:11948398KEA:17570479ProtMapper:10197446 |
| KPCD | Q05655 | KPCD1 | Q15139 | Yes | Yes | No | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018SIGNOR:15024053ProtMapper:15024053ProtMapper:15212693phosphoELM:15024053KEA:11948398KEA:15383279ProtMapper:23109817KEA:11741879PhosphoSite:21726532 |
| KPCD1 | Q15139 | RABE1 | Q15276 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22975325SIGNOR:22975325PhosphoSite:22975325 |
| KPCD1 | Q15139 | SNAI1 | O95863 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20940406PhosphoSite:20940406PhosphoSite:22791710ProtMapper:22791710ProtMapper:24556840ProtMapper:21680539PhosphoSite:22276203ProtMapper:20940406ProtMapper:25203322ProtMapper:26848698ProtMapper:28056869PhosphoSite:19923321ProtMapper:32825729ProtMapper:29789636ProtMapper:30927556ProtMapper:24954011ProtMapper:25122124ProtMapper:24565133 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
3D Structural Models
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance
Disease Involvement
Disease variantEctodermal dysplasia
Related Diseases
Biomarker
Investigative
Drugs
Interaction Protein
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid