Protein detail

KPCD1

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Entry name KPCD1	UniProt ID Q15139	EVMP confidence score 0.72
Supporting publications (n) 16	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Ensembl

ENSG00000184304

Entrez Gene Symbol

PRKD1

Gene Synonym (4)

PKC-muPKCMPKDPRKCM

Gene Description

Protein kinase D1

Chromosome

Position

29576479-30191898

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Cellular Component (10)

Molecular Function (11)

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Biological Process (3)

KEGG (3)

Reactome (3)

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence137

Enzyme-Mediated Modification (68)

68 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD1	PRKCA	P17252	S	742	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 ProtMapper:15212693 KEA:11948398 KEA:15383279 phosphoELM:15383279 SIGNOR:10197446 KEA:11741879 phosphoELM:11948398 KEA:17570479 ProtMapper:10197446
PRKD1	PRKCA	P17252	S	738	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 ProtMapper:15212693 KEA:11948398 KEA:15383279 phosphoELM:15383279 SIGNOR:10197446 KEA:11741879 phosphoELM:11948398 KEA:17570479 ProtMapper:10197446
PRKD1	PRKCA	P17252	S	412	phosphorylation	PhosphoSite
PRKD1	PRKCA	P17252	S	205	phosphorylation	PhosphoNetworks
PRKD1	PRKCA	P17252	S	420	phosphorylation	PhosphoNetworks
PRKD1	PRKCA	P17252	S	249	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:10867018
PRKD1	PRKCH	P24723	S	742	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 phosphoELM:15024053 KEA:11948398 KEA:15383279 SIGNOR:10197446 KEA:11741879 ProtMapper:10197446
PRKD1	PRKCH	P24723	S	738	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 phosphoELM:11741879 phosphoELM:15024053 KEA:11948398 KEA:15383279 SIGNOR:10197446 HPRD:10867018 KEA:11741879 ProtMapper:10197446 HPRD:11741879
PRKD1	PRKCH	P24723	S	549	phosphorylation	PhosphoNetworks
PRKD1	PRKCD	Q05655	S	742	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 SIGNOR:15024053 ProtMapper:15024053 ProtMapper:15212693 phosphoELM:15024053 KEA:11948398 KEA:15383279 KEA:11741879

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Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (59)

59 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD1	Q15139	SRC8	Q14247	Yes	No	Yes	Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:21680539 ProtMapper:19038333 SIGNOR:20363754 ProtMapper:29152154 ProtMapper:31727638 ProtMapper:26490115 ProtMapper:20363754 SIGNOR:19038333
KPCD1	Q15139	FA83G	A6ND36	Yes	Yes	No	PhosphoSite_norefSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:32570757 SIGNOR:32570757
KPCD1	Q15139	RTKN	Q9BST9	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSite	ProtMapper:24025634 PhosphoSite:22228765 SIGNOR:22228765
KPCD1	Q15139	P85A	P27986	Yes	Yes	No	iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:23129748
KPCD1	Q15139	ATP7B	P35670	Yes	Yes	No	PhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21189263 PhosphoSite:19520855 SIGNOR:21189263
KPCD1	Q15139	PK3C3	Q8NEB9	Yes	Yes	No	RLIMS-P_ProtMapperSIGNORProtMapper	SIGNOR:22095288 ProtMapper:22095288
KPCA	P17252	KPCD1	Q15139	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksKinexus_KEAWangPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperPhosphoSite	KEA:15024053 KEA:10867018 ProtMapper:15212693 KEA:11948398 KEA:15383279 phosphoELM:15383279 SIGNOR:10197446 PhosphoSite:18337243 KEA:11741879 phosphoELM:11948398 KEA:17570479 ProtMapper:10197446
KPCD	Q05655	KPCD1	Q15139	Yes	Yes	No	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 SIGNOR:15024053 ProtMapper:15024053 ProtMapper:15212693 phosphoELM:15024053 KEA:11948398 KEA:15383279 ProtMapper:23109817 KEA:11741879 PhosphoSite:21726532
KPCD1	Q15139	RABE1	Q15276	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:22975325 SIGNOR:22975325 PhosphoSite:22975325
KPCD1	Q15139	SNAI1	O95863	Yes	No	Yes	Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:20940406 PhosphoSite:20940406 PhosphoSite:22791710 ProtMapper:22791710 ProtMapper:24556840 ProtMapper:21680539 PhosphoSite:22276203 ProtMapper:20940406 ProtMapper:25203322 ProtMapper:26848698 ProtMapper:28056869 PhosphoSite:19923321 ProtMapper:32825729 ProtMapper:29789636 ProtMapper:30927556 ProtMapper:24954011 ProtMapper:25122124 ProtMapper:24565133

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains8

Sequences

Length

912

Mass

101,704

Sequence

MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL

Domain & Motif Annotations

Zinc Finger

146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2

Domain (FT)

422..541; PH; 583..839; Protein kinase

Region

377..402; Disordered

Protein Families (3)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance8

Disease Involvement (2)

Disease variantEctodermal dysplasia

Related Diseases (2)

Solid tumour/cancer Urinary system disease

Biomarker

Investigative

Drugs (10)

UCN-01 GSK-690693 SOTRASTAURIN ARGIPRESSIN BRYOSTATIN MIDOSTAURIN RESVERATROL BRYOSTATIN 1 CEP-2563 QUERCETIN

Antibody (2)

CAB018367 HPA029834

Interaction Protein (3)

ENSG00000065054ENSG00000108561ENSG00000125148

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications16

PMID	Title	Abstract
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No abstract available
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
32944193	Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.	No abstract available
33919183	Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available

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