Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Entry name KPCD1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component (10)
Molecular Function (11)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
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Biological Process (3)
KEGG (3)
Reactome (3)
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence137
Enzyme-Mediated Modification (68)
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | PRKCA | P17252 | S | 742 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018ProtMapper:15212693KEA:11948398KEA:15383279phosphoELM:15383279SIGNOR:10197446KEA:11741879phosphoELM:11948398KEA:17570479ProtMapper:10197446 |
| PRKD1 | PRKCA | P17252 | S | 738 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018ProtMapper:15212693KEA:11948398KEA:15383279phosphoELM:15383279SIGNOR:10197446KEA:11741879phosphoELM:11948398KEA:17570479ProtMapper:10197446 |
| PRKD1 | PRKCA | P17252 | S | 412 | phosphorylation | PhosphoSite | |
| PRKD1 | PRKCA | P17252 | S | 205 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCA | P17252 | S | 420 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCA | P17252 | S | 249 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:10867018 |
| PRKD1 | PRKCH | P24723 | S | 742 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018phosphoELM:15024053KEA:11948398KEA:15383279SIGNOR:10197446KEA:11741879ProtMapper:10197446 |
| PRKD1 | PRKCH | P24723 | S | 738 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018phosphoELM:11741879phosphoELM:15024053KEA:11948398KEA:15383279SIGNOR:10197446HPRD:10867018KEA:11741879ProtMapper:10197446HPRD:11741879 |
| PRKD1 | PRKCH | P24723 | S | 549 | phosphorylation | PhosphoNetworks | |
| PRKD1 | PRKCD | Q05655 | S | 742 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15024053KEA:10867018SIGNOR:15024053ProtMapper:15024053ProtMapper:15212693phosphoELM:15024053KEA:11948398KEA:15383279KEA:11741879 |
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Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (59)
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK13 | O15264 | KPCD1 | Q15139 | Yes | No | Yes | dbPTMSPIKE_LCiPTMnetSIGNOR | SIGNOR:19135240dbPTM:19369195dbPTM:19413330SPIKE_LC:19135240dbPTM:19135240 |
| KPCD1 | Q15139 | CERT | Q9Y5P4 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperReactome_ProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19005213ProtMapper:17591919dbPTM:17591919PhosphoSite:23676904PhosphoSite:29541394PhosphoSite:29848549PhosphoSite:17591919PhosphoSite:28652409ProtMapper:22226883ProtMapper:25889812SIGNOR:17591919ProtMapper:23608234PhosphoSite:17442665ProtMapper:19005213 |
| KPCD1 | Q15139 | CTNB1 | P35222 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22511927ProtMapper:29108267PhosphoSite:29108267SIGNOR:19141652ProtMapper:19141652ProtMapper:26895471 |
| KPCD1 | Q15139 | NOS1 | P29475 | Yes | Yes | No | Lit-BM-17SIGNORSparser_ProtMapperProtMapper | ProtMapper:24740233Lit-BM-17:24740233SIGNOR:24740233 |
| KPCD1 | Q15139 | CXCR4 | P61073 | Yes | No | Yes | RLIMS-P_ProtMapperREACH_ProtMapperSIGNORProtMapper | SIGNOR:27127886ProtMapper:27127886 |
| KPCD1 | Q15139 | DYL1 | P63167 | Yes | No | Yes | SIGNOR | SIGNOR:21087603 |
| KPCD1 | Q15139 | AP2B | Q92481 | Yes | No | Yes | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:31492751SIGNOR:31492751 |
| KPCD1 | Q15139 | NLRP3 | Q96P20 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:33627128ProtMapper:33850310ProtMapper:31036962SIGNOR:28716882ProtMapper:30844378 |
| KPCD1 | Q15139 | BAD | Q92934 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:20179209PhosphoSite:12531792SIGNOR:20179209 |
| KPCD1 | Q15139 | ST17B | O94768 | Yes | Yes | No | SIGNOR | SIGNOR:21148796 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains8
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance8
Disease Involvement (2)
Disease variantEctodermal dysplasia
Related Diseases (2)
Biomarker
Investigative
Drugs (10)
Interaction Protein (3)
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications16
| PMID | Title | Abstract |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32944193 | Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. | No abstract available |
| 33919183 | Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
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