Protein detail

AAAT

Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)

Entry name
AAAT
UniProt ID
Q15758
EVMP confidence score
0.88
Supporting publications (n)
25
Transmembrane count
8
Protein classification
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)
Protein Class (6)
FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
  • Transporters:Electrochemical Potential-driven transporters
  • FDA approved drug targets:Small molecule drugs
  • Predicted intracellular proteins
Transmembrane
52..81; Helical; Name=1; 95..116; Helical; Name=2; 131..153; Helical; Name=3; 225..248; Helical; Name=4; 258..285; Helical; Name=5; 307..328; Helical; Name=6; 374..400; Helical; Name=7; 461..482; Helical; Name=8
Transmembrane Count
8
Ensembl
ENSG00000105281
Entrez Gene Symbol
SLC1A5
Gene Synonym (4)
AAATASCT2M7V1RDRC
Gene Description
Solute carrier family 1 member 5
Chromosome
19
Position
46774883-46788594
Supporting publications (n)
25
EVMP confidence score
0.88
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function (3)
  • Transporters:Electrochemical Potential-driven transporters
  • FDA approved drug targets:Small molecule drugs
  • Predicted intracellular proteins
Cellular Component (5)
Molecular Function (12)
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Biological Process (3)
KEGG (2)
Reactome (10)
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence28

Ligand-Receptor Signaling (25)

25 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneCellPhoneDBNoNoNoNoNo
transmembranetransmembraneTopDBNoNoNoNoNo
transmembranetransmembraneLOCATENoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
peripheralperipheralUniProt_topologyNoNoNoNoNo
peripheralperipheralOmniPathNoNoNoNoNo
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
SLC1A5Q157583PDBPDB:6mp6PDB:7bcsPDB:7bctPDB:6mpbPDB:6rvyPDB:7bcqPDB:8oudPDB:6rvxPDB:8qroPDB:6gct
ERVW-1SLC1A5Q15758Q9UQF03:1PDBPDB:8oujPDB:8ouh

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometryWestern blotting137886648
Sequence, Structure & Domains13

Sequences

Length
541
Mass
56,598
Sequence
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=3; Comment=A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.; Name=1; IsoId=Q15758-1; Sequence=Displayed; Name=2; IsoId=Q15758-2; Sequence=VSP_046354; Name=3; IsoId=Q15758-3; Sequence=VSP_046851
Alternative Sequence
1..228; Missing (in isoform 3); 1..203; MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRS -> M (in isoform 2)

3D Structural Models

Turn
169..173; 354..356; 432..435; 457..459
Helix
44..51; 53..74; 77..117; 121..153; 160..162; 165..168; 180..191; 196..199; 231..248; 249..252; 253..291; 295..318; 320..329; 333..339; 341..350; 357..368; 372..385; 388..404; 411..427; 436..445; 450..452; 453..456; 460..488
Beta Strand
157..159; 202..209; 214..216; 220..228
3D Structure
Electron microscopy (19); X-ray crystallography (4)

Domain & Motif Annotations

Domain (CC)
The transport domain consists of four transmembrane regions 3, 6, 7 and 8 and two helical hairpins HP1 and HP2. According to the one-gate elevator transport model, substrate binding and release is controlled by HP2 which acts as a gate for the transport domain. HP2 gate opening enables substrate binding or release. The gate closes once one amino acid and up to three sodium ions bind to the transport domain, which subsequently triggers transmembrane elevator-like motion of the transporter across the plasma membrane.; DOMAIN: The beta-hairpin (aa 204-224) located between the helical segments of TM4 protrudes in the extracellular space and forms a docking platform for proteins of retroviral origin.
Region
204..224; Beta-hairpin; 511..541; Disordered
Protein Families (2)
  • Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
  • SLC1A5 subfamily
Sequence Similarities
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
Clinical Relevance7
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
GLUTAMINE
Antibody (2)
HPA035239HPA035240
Interaction Protein (3)
ENSG00000103496ENSG00000103769ENSG00000115902
Interaction Count
3
Interaction Dataset
biogrid_opencell
Supporting Publications25
PMIDTitleAbstract
32795414Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
33114768Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma.No abstract available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No abstract available
36635400Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.No abstract available
37862381Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.No abstract available
38136601Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study.No abstract available
38441169Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia.No abstract available
38490958Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer.No abstract available
38564289Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer.No abstract available
39949490CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.No abstract available
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