Protein detail
ACHA2
Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2)
Entry name ACHA2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2)
Protein Function (4)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
265..289; Helical; 297..315; Helical; 331..352; Helical; 503..521; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway7
Protein Function (4)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component (9)
Molecular Function (4)
Biological Process (3)
Reactome (7)
- R-hsa-181431 acetylcholine binding and downstream events
- R-hsa-629597 highly calcium permeable nicotinic acetylcholine receptors
- R-hsa-629594 highly calcium permeable postsynaptic nicotinic acetylcholine receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-622323 presynaptic nicotinic acetylcholine receptors
- R-hsa-112315 transmission across chemical synapses
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence40
Ligand-Receptor Signaling (36)
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | No | No |
| receptor | receptor | CellPhoneDB | No | Yes | No | No | No |
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| gaba_ach | receptor | Almen2009 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AcetylcholineReceptor_a2b3 | CHRNA2CHRNB3 | Q05901Q15822 | 1:1 | CellPhoneDB | CellPhoneDB:AcetylcholineReceptor_a2b3 | |
| CHRNA2-CHRNB4 complex | CHRNA2CHRNB4 | P30926Q15822 | 1:1 | CORUMComplexPortal | CORUM:6440intact:EBI-9009014 | 254601851949841722309577103539888906617194810631475529219126755 |
| Neuronal nicotinic acetylcholine receptor complexalpha2-beta2 | CHRNA2CHRNB2 | P17787Q15822 | 1:1 | ComplexPortal | intact:EBI-9008617 | 25460185223095771090829710353988194810631475529219126755 |
| CHRNA2 | Q15822 | 5 | PDB | PDB:5fjv |
Sequence, Structure & Domains12
Sequences
Length
529
Mass
59,765
Sequence
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15822-1; Sequence=Displayed; Name=2; IsoId=Q15822-2; Sequence=VSP_055156
Alternative Sequence
82..96; Missing (in isoform 2)
3D Structural Models
Turn
100..103; 124..129; 137..139; 148..150; 167..169; 208..210; 217..219
Helix
61..69; 118..120
Beta Strand
74..76; 78..82; 84..99; 104..116; 131..136; 145..147; 162..166; 170..173; 176..182; 190..192; 198..205; 211..215; 237..245; 248..258
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Region
27..56; Disordered
Protein Families (3)
- Ligand-gated ion channel (TC 1.A.9) family
- Acetylcholine receptor (TC 1.A.9.1) subfamily
- Alpha-2/CHRNA2 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
Clinical Relevance3
Related Diseases (5)
Biomarker
Approved
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 29045505 | Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients. | Proteomic analysis of the exosome 'surfaceome' revealed multiple PDAC-specific biomarker candidates: CLDN4, EPCAM, CD151, LGALS3BP, HIST2H2BE, and HIST2H2BF. Droplet digital PCR was used on 74 patients (136 total exosome samples) to determine baseline KRAS mutation call rates while patients were on therapy. KRAS mutations in total exosomes were detected in 44.1% of patients undergoing active therapy compared with 73.0% following exosome capture using the selected biomarkers. |