Protein detail
ACHA2
Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2)
Protein symbol ACHA2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2)
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
265..289; Helical; 297..315; Helical; 331..352; Helical; 503..521; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-181431 acetylcholine binding and downstream events
- R-hsa-629597 highly calcium permeable nicotinic acetylcholine receptors
- R-hsa-629594 highly calcium permeable postsynaptic nicotinic acetylcholine receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-622323 presynaptic nicotinic acetylcholine receptors
- R-hsa-112315 transmission across chemical synapses
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AcetylcholineReceptor_a2b3 | CHRNA2CHRNB3 | Q05901Q15822 | 1:1 | CellPhoneDB | CellPhoneDB:AcetylcholineReceptor_a2b3 | |
| CHRNA2-CHRNB4 complex | CHRNA2CHRNB4 | P30926Q15822 | 1:1 | CORUMComplexPortal | CORUM:6440intact:EBI-9009014 | 254601851949841722309577103539888906617194810631475529219126755 |
| Neuronal nicotinic acetylcholine receptor complexalpha2-beta2 | CHRNA2CHRNB2 | P17787Q15822 | 1:1 | ComplexPortal | intact:EBI-9008617 | 25460185223095771090829710353988194810631475529219126755 |
| CHRNA2 | Q15822 | 5 | PDB | PDB:5fjv |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
529
Mass
59,765
Sequence
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15822-1; Sequence=Displayed; Name=2; IsoId=Q15822-2; Sequence=VSP_055156
Alternative Sequence
82..96; Missing (in isoform 2)
3D Structural Models
Turn
100..103; 124..129; 137..139; 148..150; 167..169; 208..210; 217..219
Helix
61..69; 118..120
Beta Strand
74..76; 78..82; 84..99; 104..116; 131..136; 145..147; 162..166; 170..173; 176..182; 190..192; 198..205; 211..215; 237..245; 248..258
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Region
27..56; Disordered
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Acetylcholine receptor (TC 1.A.9.1) subfamily
- Alpha-2/CHRNA2 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
Clinical Relevance
Biomarker
Approved