Protein detail
ADRM1
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
Protein symbol ADRM1 | UniProt ID | EVMP score 0.75 |
Frequency 24 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ARM1GP110PSMD16Rpn13
Gene Description
ADRM1 26S proteasome ubiquitin receptor
Chromosome
20
Position
62302093-62308862
Frequency
24
EVMP Score
0.75
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa03050 Proteasome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05169 Epstein-Barr virus infection
Reactome
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-5619084 abc transporter disorders
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-9931269 ampk induced erad and lysosome mediated degradation of pd l1 cd274
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
- R-hsa-174143 apc c mediated degradation of cell cycle proteins
- R-hsa-109581 apoptosis
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-450408 auf1 hnrnp d0 binds and destabilizes mrna
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-69017 cdk mediated phosphorylation and removal of cdc6
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-1234174 cellular response to hypoxia
- R-hsa-1500931 cell cell communication
- R-hsa-1640170 cell cycle
- R-hsa-69620 cell cycle checkpoints
- R-hsa-69278 cell cycle mitotic
- R-hsa-446728 cell junction organization
- R-hsa-9909396 circadian clock
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-389948 co inhibition by pd 1
- R-hsa-1236978 cross presentation of soluble exogenous antigens endosomes
- R-hsa-69656 cyclin a cdk2 associated events at s phase entry
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-5607761 dectin 1 mediated noncanonical nf kb signaling
- R-hsa-4641257 degradation of axin
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-9932298 degradation of cry and per proteins
- R-hsa-4641258 degradation of dvl
- R-hsa-5610780 degradation of gli1 by the proteasome
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-69306 dna replication
- R-hsa-69002 dna replication pre initiation
- R-hsa-1168372 downstream signaling events of b cell receptor bcr
- R-hsa-202424 downstream tcr signaling
- R-hsa-8854050 fbxl7 down regulates aurka during mitotic entry and in early mitosis
- R-hsa-2871837 fceri mediated nf kb activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-9793380 formation of paraxial mesoderm
- R-hsa-69615 g1 s dna damage checkpoints
- R-hsa-69481 g2 m checkpoints
- R-hsa-9758941 gastrulation
- R-hsa-9929356 gsk3b mediated proteasomal degradation of pd l1 cd274
- R-hsa-5358346 hedgehog ligand biogenesis
- R-hsa-5610787 hedgehog off state
- R-hsa-5632684 hedgehog on state
- R-hsa-5387390 hh mutants abrogate ligand secretion
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5687128 mapk6 mapk4 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-351202 metabolism of polyamines
- R-hsa-8953854 metabolism of rna
- R-hsa-453279 mitotic g1 phase and g1 s transition
- R-hsa-453274 mitotic g2 g2 m phases
- R-hsa-2555396 mitotic metaphase and anaphase
- R-hsa-68886 m phase
- R-hsa-8951664 neddylation
- R-hsa-9604323 negative regulation of notch4 signaling
- R-hsa-9675108 nervous system development
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-68949 orc1 removal from chromatin
- R-hsa-69563 p53 dependent g1 dna damage response
- R-hsa-4086400 pcp ce pathway
- R-hsa-597592 post translational protein modification
- R-hsa-5357801 programmed cell death
- R-hsa-9907900 proteasome assembly
- R-hsa-6807070 pten regulation
- R-hsa-169911 regulation of apoptosis
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9010553 regulation of expression of slits and robos
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-450531 regulation of mrna stability by proteins that bind au rich elements
- R-hsa-350562 regulation of ornithine decarboxylase odc
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909615 regulation of pd l1 cd274 post translational modification
- R-hsa-8948751 regulation of pten stability and activity
- R-hsa-5658442 regulation of ras by gaps
- R-hsa-8939902 regulation of runx2 expression and activity
- R-hsa-8941858 regulation of runx3 expression and activity
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-9948299 ribosome associated quality control
- R-hsa-9954709 ribosome quality control rqc complex extracts and degrades nascent peptide
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8939236 runx1 regulates transcription of genes involved in differentiation of hscs
- R-hsa-174113 scf beta trcp mediated degradation of emi1
- R-hsa-187577 scf skp2 mediated degradation of p27 p21
- R-hsa-2467813 separation of sister chromatids
- R-hsa-5358351 signaling by hedgehog
- R-hsa-449147 signaling by interleukins
- R-hsa-157118 signaling by notch
- R-hsa-9013694 signaling by notch4
- R-hsa-376176 signaling by robo receptors
- R-hsa-983705 signaling by the b cell receptor bcr
- R-hsa-195721 signaling by wnt
- R-hsa-9824272 somitogenesis
- R-hsa-9929491 spop mediated proteasomal degradation of pd l1 cd274
- R-hsa-69541 stabilization of p53
- R-hsa-69052 switching of origins to a post replicative state
- R-hsa-69239 synthesis of dna
- R-hsa-69242 s phase
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-202403 tcr signaling
- R-hsa-8852276 the role of gtse1 in g2 m progression after g2 checkpoint
- R-hsa-5668541 tnfr2 non canonical nf kb pathway
- R-hsa-8878171 transcriptional regulation by runx1
- R-hsa-8878166 transcriptional regulation by runx2
- R-hsa-8878159 transcriptional regulation by runx3
- R-hsa-72766 translation
- R-hsa-382551 transport of small molecules
- R-hsa-75815 ubiquitin dependent degradation of cyclin d
- R-hsa-69601 ubiquitin mediated degradation of phosphorylated cdc25a
- R-hsa-5689880 ub specific processing proteases
- R-hsa-5689603 uch proteinases
- R-hsa-180585 vif mediated degradation of apobec3g
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
11 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
407
Mass
42,153
Sequence
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
3D Structural Models
Turn
64..66; 191..195; 254..256; 349..351
Helix
99..101; 117..129; 266..273; 288..291; 294..297; 300..302; 304..310; 311..313; 324..326; 327..332; 334..348; 353..358; 363..371; 374..383
Beta Strand
23..34; 37..40; 45..51; 57..63; 69..75; 79..84; 89..91; 93..98; 104..109; 111..114; 202..204; 249..253; 276..278; 282..284; 386..388; 395..397
3D Structure
NMR spectroscopy (10); X-ray crystallography (11)
Domain & Motif Annotations
Compositional Bias
387..398; Basic and acidic residues
Domain (CC)
The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of 'Lys-48'-linked diubiquitin allows UCHL5 access to the distal subunit.
Domain (FT)
18..131; Pru; 277..391; DEUBAD
Region
194..259; Disordered; 253..407; Interaction with UCHL5; 379..407; Disordered
Protein Families
ADRM1 family
Sequence Similarities
Belongs to the ADRM1 family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000013275ENSG00000087191ENSG00000100519ENSG00000100764ENSG00000101843ENSG00000108671ENSG00000116750ENSG00000135018ENSG00000150991ENSG00000159352ENSG00000161057ENSG00000165916ENSG00000173692ENSG00000175166ENSG00000188021ENSG00000197170
Interaction Count
16
Interaction Dataset
biogrid_opencellbiogrid_bioplexintact_biogridintact_biogrid_bioplex