Protein detail

ADRM1

Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)

Entry name ADRM1	UniProt ID Q16186	EVMP confidence score 0.75
Supporting publications (n) 24	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000130706

Entrez Gene Symbol

ADRM1

Gene Synonym (4)

ARM1GP110PSMD16Rpn13

Gene Description

ADRM1 26S proteasome ubiquitin receptor

Chromosome

Position

62302093-62308862

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificCardiomyocytes

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

KEGG (9)

Reactome (134)

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Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence17

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster4	ADRM1 AGPAT1 AGPAT2 POMP PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC3 PSMC4 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMG2 PSMG3 PSMG4 RIN1 TSC1 UCHL5	A5LHX3 O00231 O00232 O00487 O14818 O15120 O43242 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P40306 P43686 P49720 P49721 P51665 P60900 P62191 Q13200 Q13671 Q15008 Q16186 Q5JS54 Q8TAA3 Q92574 Q969U7 Q99436 Q99460 Q99943 Q9BT73 Q9UNM6 Q9Y244 Q9Y5K5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3550	22036573
	ADRM1 TIMM13 TIMM8A	O60220 Q16186 Q9Y5L4	1:1:1	CompleatCFinder	Compleat:HC7708
	ADRM1 UBB	P0CG47 Q16186	2:1	PDB	PDB:5ymy
	ADRM1 PSMD1 UBB	P0CG47 Q16186 Q99460	2:2:2	PDB	PDB:6uyiPDB:5v1zPDB:6uyjPDB:5v1y
	ADRM1 UBB UCHL5	P0CG47 Q16186 Q9Y5K5	1:1:1	PDB	PDB:4uel
	ADRM1 HERC3 HERC4 HERC6 HSPA13 PSMC2 PSMD1 PSMD4 PSMD7 RAD23A UBC UBQLN1 UBQLN2 UBQLN4 UHMK1	P0CG48 P35998 P48723 P51665 P54725 P55036 Q15034 Q16186 Q5GLZ8 Q8IVU3 Q8TAS1 Q99460 Q9NRR5 Q9UHD9 Q9UMX0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5269
	ADRM1 UBC	P0CG48 Q16186	2:2	PDB	PDB:8ftq
	ADRM1 PSMD1 UBC	P0CG48 Q16186 Q99460	2:2:2	PDB	PDB:6oi4
	ADRM1 PSMD1	Q16186 Q99460	1:1	PDB	PDB:6co4
	ADRM1 UBQLN2	Q16186 Q9UHD9	1:1	PDB	PDB:2nbv

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains13

Sequences

Length

407

Mass

42,153

Sequence

MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD

3D Structural Models

Turn

64..66; 191..195; 254..256; 349..351

Helix

99..101; 117..129; 266..273; 288..291; 294..297; 300..302; 304..310; 311..313; 324..326; 327..332; 334..348; 353..358; 363..371; 374..383

Beta Strand

23..34; 37..40; 45..51; 57..63; 69..75; 79..84; 89..91; 93..98; 104..109; 111..114; 202..204; 249..253; 276..278; 282..284; 386..388; 395..397

3D Structure

NMR spectroscopy (10); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

387..398; Basic and acidic residues

Domain (CC)

The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of 'Lys-48'-linked diubiquitin allows UCHL5 access to the distal subunit.

Domain (FT)

18..131; Pru; 277..391; DEUBAD

Region

194..259; Disordered; 253..407; Interaction with UCHL5; 379..407; Disordered

Protein Families

ADRM1 family

Sequence Similarities

Belongs to the ADRM1 family.

Clinical Relevance5

Drugs (5)

IXAZOMIB CITRATE CARFILZOMIB IXAZOMIB OPROZOMIB BORTEZOMIB

Antibody

HPA042266

Interaction Protein (16)

ENSG00000013275ENSG00000087191ENSG00000100519ENSG00000100764ENSG00000101843ENSG00000108671ENSG00000116750ENSG00000135018ENSG00000150991ENSG00000159352ENSG00000161057ENSG00000165916ENSG00000173692ENSG00000175166ENSG00000188021ENSG00000197170

Interaction Count

Interaction Dataset (4)

biogrid_opencellbiogrid_bioplexintact_biogridintact_biogrid_bioplex

Supporting Publications23

PMID	Title	Abstract
32341357	CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells.	Taken together, our study results revealed that in the progress of ONFH, exosomes from the pathological bone brought about the failure of MSCs repairing the necrotic bone for lack of some critical proteins, like integrin CD41, and prompted the progression of experimentally induced ONFH-like status in the rat.
32944193	Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.	No abstract available
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34445582	Increased Angiogenesis by Exosomes Secreted by Adipose-Derived Stem Cells upon Lipopolysaccharide Stimulation.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
36398564	Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38168906	Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis.	No abstract available

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