Protein detail

UAP1

UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)

Entry name UAP1	UniProt ID Q16222	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class (4)

EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000117143

Entrez Gene Symbol

UAP1

Gene Synonym (3)

AgXAGX1SPAG2

Gene Description

UDP-N-acetylglucosamine pyrophosphorylase 1

Chromosome

Position

162561722-162601240

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificT-reg

Function & Pathway7

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (5)

Mediation Categories

Metabolism mediation

Relations & Evidence21

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (16)

16 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster251	SCLT1 SLC37A1 SLC37A2 SLC37A3 UAP1 UAP1L1	P57057 Q16222 Q3KQV9 Q8NCC5 Q8TED4 Q96NL6	1:1:1:1:1:1	Compleat	Compleat:HC1833	22036573
Intraflagellar transport complex B	CLUAP1 IFT172 IFT20 IFT22 IFT25 IFT27 IFT46 IFT52 IFT56 IFT57 IFT70B IFT74 IFT80 IFT81 IFT88 TRAF3IP1	A0AVF1 Q13099 Q8IY31 Q8N4P2 Q8TDR0 Q8WYA0 Q96AJ1 Q96LB3 Q9BW83 Q9H7X7 Q9NQC8 Q9NWB7 Q9P2H3 Q9UG01 Q9Y366 Q9Y547	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-22224582	23945166 29272450 26980730 14755292 26498262 22118932
	ANKRD55 CLUAP1 IFT172 IFT20 IFT22 IFT25 IFT27 IFT46 IFT52 IFT56 IFT57 IFT70A IFT70B IFT74 IFT80 IFT81 IFT88 TRAF3IP1	A0AVF1 Q13099 Q3KP44 Q86WT1 Q8IY31 Q8N4P2 Q8TDR0 Q8WYA0 Q96AJ1 Q96LB3 Q9BW83 Q9H7X7 Q9NQC8 Q9NWB7 Q9P2H3 Q9UG01 Q9Y366 Q9Y547	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	ASPDH RNPEP TPPP TPPP3 UAP1	A6ND91 O94811 Q16222 Q9BW30 Q9H4A4	0:0:0:0:0	hu.MAP2
	ASPDH RNPEP TPPP UAP1	A6ND91 O94811 Q16222 Q9H4A4	0:0:0:0	hu.MAP2
	CCNK CDK12 CDK18 DDX39B POLDIP3 RBM39 SRSF1 SRSF2 THOC2 UAP1 UBC	O75909 P0CG48 Q01130 Q07002 Q07955 Q13838 Q14498 Q16222 Q8NI27 Q9BY77 Q9NYV4	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4470
	CCNK CDK12 DDX39B POLDIP3 RBM39 SRSF1 SRSF2 THOC2 THOC3 UAP1	O75909 Q01130 Q07955 Q13838 Q14498 Q16222 Q8NI27 Q96J01 Q9BY77 Q9NYV4	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6645
	PPA1 RNPEP TPPP UAP1	O94811 Q15181 Q16222 Q9H4A4	0:0:0:0	hu.MAP2
	PLPBP UAP1L1	O94903 Q3KQV9	0:0	hu.MAP2
	MBL2 SERPINC1 UAP1	P01008 P11226 Q16222	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	30646616 32089743

Sequence, Structure & Domains11

Sequences

Length

522

Mass

58,769

Sequence

MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=AGX2; Synonyms=AGX-2; IsoId=Q16222-1; Sequence=Displayed; Name=AGX1; Synonyms=AGX-1; IsoId=Q16222-2; Sequence=VSP_004483; Name=3; IsoId=Q16222-3; Sequence=VSP_014523

Alternative Sequence

454..470; Missing (in isoform AGX1); 454; Missing (in isoform 3)

3D Structural Models

Turn

80..83; 168..170; 485..487

Helix

3..12; 16..19; 22..24; 27..38; 42..52; 66..68; 74..76; 84..86; 87..99; 114..116; 122..124; 135..154; 171..180; 182..185; 188..190; 223..225; 226..232; 235..242; 262..271; 304..306; 309..313; 335..343; 346..348; 382..388; 399..402; 418..435; 495..498

Beta Strand

77..79; 103..108; 119..121; 162..166; 191..195; 198..200; 210..212; 218..220; 246..251; 274..281; 291..294; 299..302; 319..323; 325..334; 352..356; 375..379; 390..396; 412..417; 439..441; 481..483; 489..491; 505..510; 513..516

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Protein Families

UDPGP type 1 family

Sequence Similarities

Belongs to the UDPGP type 1 family.

Clinical Relevance1

Antibody

HPA014659

Supporting Publications1

PMID	Title	Abstract
29635386	Amniotic Fluid Exosome Proteomic Profile Exhibits Unique Pathways of Term and Preterm Labor.	Exosomes were isolated by differential centrifugation and quantified using nanocrystals (Qdot) coupled to CD63 and placental alkaline phosphatase (PLAP) by fluorescence nanoparticle tracking analysis.