Protein detail
UAP1
UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)
Entry name UAP1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
AgXAGX1SPAG2
Gene Description
UDP-N-acetylglucosamine pyrophosphorylase 1
Chromosome
1
Position
162561722-162601240
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificT-reg
Function & Pathway7
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (5)
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-446193 biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein
- R-hsa-597592 post translational protein modification
- R-hsa-446219 synthesis of substrates in n glycan biosythesis
- R-hsa-446210 synthesis of udp n acetyl glucosamine
Mediation Categories
Metabolism mediation
Relations & Evidence21
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (16)
16 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| NEUROG2PABPC4SRP19SRP54SRP9UAP1L1 | P09132P49458P61011Q13310Q3KQV9Q9H2A3 | 0:0:0:0:0:0 | hu.MAP2 | |||
| GSSRNPEPUAP1 | P48637Q16222Q9H4A4 | 0:0:0 | hu.MAP2 | |||
| PPA1UAP1UBE2M | P61081Q15181Q16222 | 0:0:0 | hu.MAP2 | |||
| UAP1 | Q16222 | 2 | PDB | PDB:1jv1PDB:1jvgPDB:1jv3PDB:1jvdPDB:6z2f | ||
| CLUAP1IFT57TRAF3IP1 | Q8TDR0Q96AJ1Q9NWB7 | 0:0:0 | hu.MAP | |||
| CLUAP1IFT172IFT57TRAF3IP1 | Q8TDR0Q96AJ1Q9NWB7Q9UG01 | 0:0:0:0 | hu.MAP |
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Sequence, Structure & Domains11
Sequences
Length
522
Mass
58,769
Sequence
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=AGX2; Synonyms=AGX-2; IsoId=Q16222-1; Sequence=Displayed; Name=AGX1; Synonyms=AGX-1; IsoId=Q16222-2; Sequence=VSP_004483; Name=3; IsoId=Q16222-3; Sequence=VSP_014523
Alternative Sequence
454..470; Missing (in isoform AGX1); 454; Missing (in isoform 3)
3D Structural Models
Turn
80..83; 168..170; 485..487
Helix
3..12; 16..19; 22..24; 27..38; 42..52; 66..68; 74..76; 84..86; 87..99; 114..116; 122..124; 135..154; 171..180; 182..185; 188..190; 223..225; 226..232; 235..242; 262..271; 304..306; 309..313; 335..343; 346..348; 382..388; 399..402; 418..435; 495..498
Beta Strand
77..79; 103..108; 119..121; 162..166; 191..195; 198..200; 210..212; 218..220; 246..251; 274..281; 291..294; 299..302; 319..323; 325..334; 352..356; 375..379; 390..396; 412..417; 439..441; 481..483; 489..491; 505..510; 513..516
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Protein Families
UDPGP type 1 family
Sequence Similarities
Belongs to the UDPGP type 1 family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 29635386 | Amniotic Fluid Exosome Proteomic Profile Exhibits Unique Pathways of Term and Preterm Labor. | Exosomes were isolated by differential centrifugation and quantified using nanocrystals (Qdot) coupled to CD63 and placental alkaline phosphatase (PLAP) by fluorescence nanoparticle tracking analysis. |