Protein detail

S15A2

Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)

Entry name S15A2	UniProt ID Q16348	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 12	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

58..78; Helical; 84..104; Helical; 114..134; Helical; 140..160; Helical; 184..204; Helical; 218..238; Helical; 296..316; Helical; 344..364; Helical; 381..401; Helical; 612..632; Helical; 644..664; Helical; 675..695; Helical

Transmembrane Count

Ensembl

ENSG00000163406

Entrez Gene Symbol

SLC15A2

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway6

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

Canonical Pathways

M17 Pid notch pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence25

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
mfs	transporter	Surfaceome	No	Yes	No	No	No
slc15	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PDZK1 SLC15A2	Q16348 Q5T2W1	1:1	PDB	PDB:6ezi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Fetch_Error	4	32560723 37204515 39207047 32854315

Sequence, Structure & Domains12

Sequences

Length

729

Mass

81,783

Sequence

MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16348-1; Sequence=Displayed; Name=2; IsoId=Q16348-2; Sequence=VSP_043084

Alternative Sequence

113..143; Missing (in isoform 2)

3D Structural Models

Beta Strand

724..728

3D Structure

Electron microscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

24..33; Pro residues

Domain (CC)

The extracellular domain (ECD) region specifically binds trypsin.

Region

1..34; Disordered; 402..611; Extracellular domain (ECD)

Protein Families (2)

Major facilitator superfamily
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family

Sequence Similarities

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

Clinical Relevance1

Drugs (14)

LYS[Z(NO2)]-VAL 4-AMBA [3H]MIROGABALIN AC-[13C,15N]PGP LYS[Z(NO2)]-LYS[Z(NO2)]WARFARIN LYS[Z(NO2)]-PRO [14C]GLYSAR [11C]GLYSAR (3,5)-[19F]2-PHE-&PSI -ALA [3H]GLYSAR [18F]FEPPG SORAFENIB

Supporting Publications2

PMID	Title	Abstract
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available