Protein detail

S15A2

Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)

Protein symbol
S15A2
UniProt ID
EVMP score
0.25
Frequency
2
Transmembrane count
12
Protein classification
Basic Information
Protein Names
Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
58..78; Helical; 84..104; Helical; 114..134; Helical; 140..160; Helical; 184..204; Helical; 218..238; Helical; 296..316; Helical; 344..364; Helical; 381..401; Helical; 612..632; Helical; 644..664; Helical; 675..695; Helical
Transmembrane Count
12
Entrez Gene Symbol
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

23 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneTopDBNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
cell_surfacecell_surfaceSurfaceomeNoNoNoNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PDZK1SLC15A2Q16348Q5T2W11:1PDBPDB:6ezi

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyFetch_Error432560723372045153920704732854315
Sequence, Structure & Domains

Sequences

Length
729
Mass
81,783
Sequence
MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16348-1; Sequence=Displayed; Name=2; IsoId=Q16348-2; Sequence=VSP_043084
Alternative Sequence
113..143; Missing (in isoform 2)

3D Structural Models

Beta Strand
724..728
3D Structure
Electron microscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
24..33; Pro residues
Domain (CC)
The extracellular domain (ECD) region specifically binds trypsin.
Region
1..34; Disordered; 402..611; Extracellular domain (ECD)
Protein Families
  • Major facilitator superfamily
  • Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
Sequence Similarities
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Clinical Relevance