Protein detail
PKN1
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Entry name PKN1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Protein Class
EnzymesPredicted intracellular proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:AGC Ser/Thr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DBKMGC46204PAK1PKNPRK1PRKCL1
Gene Description
Protein kinase N1
Chromosome
19
Position
14433053-14471867
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineBrain Regional SpecificcerebellumCell SpecificEnterocytesBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:AGC Ser/Thr protein kinases
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0003682 chromatin binding
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0030374 nuclear receptor coactivator activity
- GO:0031267 small GTPase binding
- GO:0035402 histone H3T11 kinase activity
- GO:0042393 histone binding
- GO:0042826 histone deacetylase binding
- GO:0050681 nuclear androgen receptor binding
- GO:0106310 protein serine kinase activity
Biological Process
KEGG
Reactome
- R-hsa-5625886 activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-5625740 rho gtpases activate pkns
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKN1 | PDPK1 | O15530 | T | 774 | phosphorylation | SIGNORProtMapperHPRDdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:10792047KEA:10792047ProtMapper:10753910HPRD:18669648HPRD:10753910KEA:10753910SIGNOR:10753910HPRD:10792047phosphoELM:10792047 |
| PKN1 | PDPK1 | O15530 | T | 780 | phosphorylation | HPRDKEA | HPRD:10792047KEA:10753910KEA:10792047HPRD:18669648 |
| PKN1 | PDPK1 | O15530 | S | 773 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PKN1 | CDK1 | P06493 | S | 537 | phosphorylation | PhosphoSite | |
| PKN1 | CDK1 | P06493 | S | 562 | phosphorylation | PhosphoSite | |
| PKN1 | CDK1 | P06493 | S | 916 | phosphorylation | PhosphoSiteKEA | KEA:17570479 |
| PKN1 | CDK1 | P06493 | S | 533 | phosphorylation | PhosphoSite | |
| PKN1 | PDK1 | Q15118 | T | 780 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PKN1 | PDK1 | Q15118 | T | 774 | phosphorylation | KEA | KEA:10792047KEA:10753910 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
18 records.
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Protein Complex Composition
8 records.
Sequence, Structure & Domains
Sequences
Length
942
Mass
103,932
Sequence
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16512-1; Sequence=Displayed; Name=2; IsoId=Q16512-2; Sequence=VSP_038143; Name=3; IsoId=Q16512-3; Sequence=VSP_039213, VSP_039214
Alternative Sequence
1..7; MASDAVQ -> MAEANNPSEQELE (in isoform 2); 603; S -> R (in isoform 3); 604..942; Missing (in isoform 3)
3D Structural Models
Turn
122..124; 157..159; 635..637; 672..674; 707..709; 854..856; 862..864; 931..934
Helix
15..18; 29..66; 71..95; 126..151; 160..187; 612..614; 648..653; 657..671; 703..706; 714..733; 743..745; 779..781; 784..788; 794..810; 820..829; 840..849; 865..869; 872..874; 879..883; 906..909; 926..930
Beta Strand
194..196; 615..624; 627..634; 640..647; 681..686; 688..696; 700..702; 746..748; 750..752; 754..756; 763..765
3D Structure
NMR spectroscopy (2); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
581..596; Polar residues
Domain (CC)
The C1 domain does not bind the diacylglycerol (DAG).
Domain (FT)
25..100; REM-1 1; 112..193; REM-1 2; 201..280; REM-1 3; 307..470; C2; 615..874; Protein kinase; 875..942; AGC-kinase C-terminal
Region
102..121; Disordered; 181..185; Important for interaction with bacterial SspH1 and SspH1-mediated polyubiquitination; 341..363; Disordered; 553..603; Disordered
Protein Families
- Protein kinase superfamily
- AGC Ser/Thr protein kinase family
- PKC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Clinical Relevance
Drug Targets
Literature-reported target
Interaction Protein
ENSG00000026025ENSG00000056558ENSG00000127191ENSG00000140743ENSG00000175602ENSG00000204713ENSG00000277586
Interaction Count
7
Interaction Dataset
intact_biogrid