Protein detail
KGUA
Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
Protein symbol KGUA | UniProt ID | EVMP score 0.75 |
Frequency 23 | Transmembrane count | Protein classification EnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
Protein Class
EnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Guanylate kinase 1
Chromosome
1
Position
228139962-228148984
Frequency
23
EVMP Score
0.75
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 40595564 |
Sequence, Structure & Domains
Sequences
Length
197
Mass
21,726
Sequence
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16774-1; Sequence=Displayed; Name=2; IsoId=Q16774-2; Sequence=VSP_043778; Name=3; IsoId=Q16774-3; Sequence=VSP_043778, VSP_047372
Alternative Sequence
1; M -> MLRRPLAGLAAAALGRAPPDGM (in isoform 2 and isoform 3); 159..197; SKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA -> RNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPWQAIRQLCALGQHVEWRRCCPCGWNILG (in isoform 3)
3D Structural Models
Turn
29..31; 49..51; 162..164
Helix
17..27; 58..67; 85..93; 104..111; 127..137; 142..158; 174..193
Beta Strand
7..11; 12..14; 32..34; 38..41; 70..76; 79..84; 97..101; 118..123; 166..170
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
4..186; Guanylate kinase-like
Protein Families
Guanylate kinase family
Sequence Similarities
Belongs to the guanylate kinase family.
Clinical Relevance
Disease Involvement
Disease variant
Antibody